Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

Canonical Wnt signaling pathway, mediated by the transcription factor β-catenin, plays critical roles in embryonic development, and represents an important therapeutic target. In a zebrafish-based in vivo screen for small molecules that specifically perturb embryonic dorsoventral patterning, we disc...

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Autori principali: Hao, Jijun, Ao, Ada, Zhou, Li, Murphy, Clare K., Frist, Audrey Y., Keel, Jessica J., Thorne, Curtis A., Kim, Kwangho, Lee, Ethan, Hong, Charles C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923627/
https://ncbi.nlm.nih.gov/pubmed/24012757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.047
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