An In vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog signaling Inhibition

Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been widely accepted as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhibition, Smo gain of function mutations have limited their...

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Publicado en:Cell Rep
Autores principales: Williams, Charles H., Hempel, Jonathan E., Hao, Jijun, Frist, Audrey Y., Williams, Michelle M., Fleming, Jonathan T., Sulikowski, Gary A., Cooper, Michael K., Chiang, Chin, Hong, Charles C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394042/
https://ncbi.nlm.nih.gov/pubmed/25818300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.001
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