Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action

Por Hempel, Jonathan E., Cadar, Adrian G., Hong, Charles C.
Publicado no Bioorg Med Chem Lett (2016)

Assignment and Stereocontrol of Hibarimicin Atropoisomers

Por Romaine, Ian M., Hempel, Jonathan E., Shanmugam, Ganesh, Hori, Hiroshi, Igarashi, Yasuhiro, Polavarapu, Prasad L., Sulikowski, Gary A.
Publicado em 2011

An In vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog signaling Inhibition

Por Williams, Charles H., Hempel, Jonathan E., Hao, Jijun, Frist, Audrey Y., Williams, Michelle M., Fleming, Jonathan T., Sulikowski, Gary A., Cooper, Michael K., Chiang, Chin, Hong, Charles C.
Publicado no Cell Rep (2015)

The application of vinylogous iminium salt derivatives to efficient formal syntheses of the marine akaloids lamellarin G trimethyl ether and ningalin B

Por Gupton, John T., Giglio, Benjamin C., Eaton, James E., Rieck, Elizabeth A., Smith, Kristin L., Keough, Matthew J., Barelli, Peter J., Firich, Lauren T., Hempel, Jonathan E., Smith, Timothy M., Kanters, Rene P.F.
Publicado em 2009

Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Por Feaster, Tromondae K., Cadar, Adrian G., Wang, Lili, Williams, Charles H., Chun, Young Wook, Hempel, Jonathan E., Bloodworth, Nathaniel, Merryman, W. David, Lim, Chee Chew, Wu, Joseph C., Knollmann, Björn C., Hong, Charles C.
Publicado no Circ Res (2015)

The Application of Vinylogous Iminium Salt Derivatives and Microwave Accelerated Vilsmeier-Haack Reactions to Efficient Relay Syntheses of the Polycitone and Storniamide Natural Pr...

Por Gupton, John T., Banner, Edith J., Sartin, Melissa D., Coppock, Matthew B., Hempel, Jonathan E., Kharlamova, Anastasia, Fisher, Daniel C., Giglio, Ben C., Smith, Kristin L., Keough, Matt J., Smith, Timothy M., Kanters, Rene P.F., Dominey, Raymond N., Sikorski, James A.
Publicado em 2008