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Development of a fission yeast-based high throughput screen to identify chemical regulators of cAMP phosphodiesterases
Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of enzymes that serve as drug targets in many human diseases. There is a continuing need to identify high-specificity inhibitors that affect individual PDE families or even subtypes within a single family. We describe a fission yeast...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851203/ https://ncbi.nlm.nih.gov/pubmed/18227226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057107312127 |
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