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New classes of PDE7 inhibitors identified by a fission yeast-based HTS
Studies of the phosphodiesterase PDE7 family are impeded by there being only one commercially-available PDE7 inhibitor, BRL50481. We have employed a high throughput screen of commercial chemical libraries, using a fission yeast-based assay, to identify PDE7 inhibitors that include steroids, podocarp...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854023/ https://ncbi.nlm.nih.gov/pubmed/20228279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057110362100 |
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