Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays

We previously constructed a collection of fission yeast strains that express various mammalian cyclic nucleotide phosphodiesterases (PDEs) and developed a cell-based high throughput screen (HTS) for small molecule PDE inhibitors. Here we describe a compound, BC54, that is a selective inhibitor of en...

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Gepubliceerd in:Cell Signal
Hoofdauteurs: de Medeiros, Ana Santos, Wyman, Arlene R., Alaamery, Manal A., Allain, Christina, Ivey, F. Douglas, Wang, Lili, Le, Hai, Morken, James P., Habara, Alawi, Le, Cuong, Cui, Shuaiying, Lerner, Adam, Hoffman, Charles S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651194/
https://ncbi.nlm.nih.gov/pubmed/28867658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.08.011
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