Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays

We previously constructed a collection of fission yeast strains that express various mammalian cyclic nucleotide phosphodiesterases (PDEs) and developed a cell-based high throughput screen (HTS) for small molecule PDE inhibitors. Here we describe a compound, BC54, that is a selective inhibitor of en...

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Publicat a:Cell Signal
Autors principals: de Medeiros, Ana Santos, Wyman, Arlene R., Alaamery, Manal A., Allain, Christina, Ivey, F. Douglas, Wang, Lili, Le, Hai, Morken, James P., Habara, Alawi, Le, Cuong, Cui, Shuaiying, Lerner, Adam, Hoffman, Charles S.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651194/
https://ncbi.nlm.nih.gov/pubmed/28867658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.08.011
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