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A Fission Yeast-based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity
Fission yeast strains have been engineered so that their growth behavior reflects the activity of heterologous cyclic nucleotide phosphodiesterases (PDEs). These strains can be used in High Throughput Screens (HTSs) for PDE inhibitors that possess ‘drug-like’ characteristics, displaying activity in...
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| Publicado no: | Handb Exp Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4417485/ https://ncbi.nlm.nih.gov/pubmed/21695638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-642-17969-3_5 |
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