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Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling
We have developed a robust in vivo small molecule screen that modulates heart size and cardiomyocyte generation in zebrafish. Three structurally-related compounds (Cardionogen-1 to -3) identified from our screen enlarge the size of the developing heart via myocardial hyperplasia. Increased cardiomyo...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3645312/ https://ncbi.nlm.nih.gov/pubmed/22195568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.09.015 |
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