Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling

We have developed a robust in vivo small molecule screen that modulates heart size and cardiomyocyte generation in zebrafish. Three structurally-related compounds (Cardionogen-1 to -3) identified from our screen enlarge the size of the developing heart via myocardial hyperplasia. Increased cardiomyo...

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Autors principals: Ni, Terri T., Rellinger, Eric J., Mukherjee, Amrita, Stephens, Lauren, Thorne, Cutris A, Kim, Kwangho, Hu, Jiangyong, Xie, Shuying, Lee, Ethan, Marnett, Larry, Hatzopoulos, Antonis K., Zhong, Tao P.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645312/
https://ncbi.nlm.nih.gov/pubmed/22195568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.09.015
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