Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase

Wnt/β-catenin signal transduction directs metazoan development and is deregulated in numerous human congenital disorders and cancers. In the absence of Wnt stimulation, a multiprotein “destruction complex,” assembled by the scaffold protein Axin, targets the key transcriptional activator β-catenin f...

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Bibliographic Details
Published in:Genetics
Main Authors: Wang, Zhenghan, Tacchelly-Benites, Ofelia, Yang, Eungi, Thorne, Curtis A., Nojima, Hisashi, Lee, Ethan, Ahmed, Yashi
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2016
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858779/
https://ncbi.nlm.nih.gov/pubmed/26975665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.183244
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