Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC

The aberrant activation of Wnt signal transduction initiates the development of 90% of colorectal cancers, the majority of which arise from inactivation of the tumor suppressor Adenomatous polyposis coli (APC). In the classical model for Wnt signaling, the primary role of APC is to act, together wit...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Tacchelly-Benites, Ofelia, Wang, Zhenghan, Yang, Eungi, Benchabane, Hassina, Tian, Ai, Randall, Michael P., Ahmed, Yashi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800574/
https://ncbi.nlm.nih.gov/pubmed/29408853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007178
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