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Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
The aberrant activation of Wnt signal transduction initiates the development of 90% of colorectal cancers, the majority of which arise from inactivation of the tumor suppressor Adenomatous polyposis coli (APC). In the classical model for Wnt signaling, the primary role of APC is to act, together wit...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5800574/ https://ncbi.nlm.nih.gov/pubmed/29408853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007178 |
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