2-Hydroxyglutarate is not a metabolite; d-2-hydroxyglutarate and l-2-hydroxyglutarate are!

Por Struys, Eduard A.
Publicado em 2013

Progress in understanding 2-hydroxyglutaric acidurias

Por Kranendijk, Martijn, Struys, Eduard A., Salomons, Gajja S., Van der Knaap, Marjo S., Jakobs, Cornelis
Publicado em 2012

The measurement of urinary Δ(1)-piperideine-6-carboxylate, the alter ego of α-aminoadipic semialdehyde, in Antiquitin deficiency

Por Struys, Eduard A., Bok, Levinus A., Emal, Dina, Houterman, Saskia, Willemsen, Michel A., Jakobs, Cornelis
Publicado em 2012

A catabolic block does not sufficiently explain how 2-deoxy-d-glucose inhibits cell growth

Por Ralser, Markus, Wamelink, Mirjam M., Struys, Eduard A., Joppich, Christian, Krobitsch, Sylvia, Jakobs, Cornelis, Lehrach, Hans
Publicado em 2008

Ribose-5-Phosphate Isomerase Deficiency: New Inborn Error in the Pentose Phosphate Pathway Associated with a Slowly Progressive Leukoencephalopathy

Por Huck, Jojanneke H. J., Verhoeven, Nanda M., Struys, Eduard A., Salomons, Gajja S., Jakobs, Cornelis, van der Knaap, Marjo S.
Publicado em 2004

Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming

Por Prigione, Alessandro, Lichtner, Björn, Kuhl, Heiner, Struys, Eduard A., Wamelink, Mirjam, Lehrach, Hans, Ralser, Markus, Timmermann, Bernd, Adjaye, James
Publicado no Stem Cells (2014)

Mutations in the d-2-Hydroxyglutarate Dehydrogenase Gene Cause d-2-Hydroxyglutaric Aciduria

Por Struys, Eduard A., Salomons, Gajja S., Achouri, Younes, Van Schaftingen, Emile, Grosso, Salvatore, Craigen, William J., Verhoeven, Nanda M., Jakobs, Cornelis
Publicado em 2005

Guanidinoacetate Methyltransferase Activity in Lymphocytes, for a Fast Diagnosis

Por Berends, Lisette M., Struys, Eduard A., Roos, Birthe, Holwerda, Ulbe, Jansen, Erwin E. W., Salomons, Gajja S., Wamelink, Mirjam M. C.
Publicado no JIMD Rep (2017)

Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4(+) T Cells

Por Hegedus, Andrea, Kavanagh Williamson, Maia, Khan, Mariam B., Dias Zeidler, Julianna, Da Poian, Andrea T., El-Bacha, Tatiana, Struys, Eduard A., Huthoff, Hendrik
Publicado no AIDS Res Hum Retroviruses (2017)

No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture

Por van Ziel, Anna M., Wolzak, Kimberly, Nölle, Anna, Hoetjes, Petrus J., Berenjeno‐Correa, Ernesto, van Anken, Eelco, Struys, Eduard A., Scheper, Wiep
Publicado no J Neurochem (2019)

Transaldolase Deficiency: Liver Cirrhosis Associated with a New Inborn Error in the Pentose Phosphate Pathway

Por Verhoeven, Nanda M., Huck, Jojanneke H. J., Roos, Birthe, Struys, Eduard A., Salomons, Gajja S., Douwes, Adriaan C., van der Knaap, Marjo S., Jakobs, Cornelis
Publicado em 2001

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

Por Ralser, Markus, Wamelink, Mirjam M, Kowald, Axel, Gerisch, Birgit, Heeren, Gino, Struys, Eduard A, Klipp, Edda, Jakobs, Cornelis, Breitenbach, Michael, Lehrach, Hans, Krobitsch, Sylvia
Publicado em 2007

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia

Por Wiseman, Daniel H., Williams, Emma L., Wilks, Deepti P., Sun Leong, Hui, Somerville, Tim D. D., Dennis, Michael W., Struys, Eduard A., Bakkali, Abdellatif, Salomons, Gajja S., Somervaille, Tim C. P.
Publicado no Leukemia (2016)

IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis

Por Gao, Ya, de Wit, Maurice, Struys, Eduard A., van der Linde, Herma C. Z., Salomons, Gajja S., Lamfers, Martine L. M., Willemsen, Rob, Sillevis Smitt, Peter A. E., French, Pim J.
Publicado no PLoS One (2018)

In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site

Por Chaturvedi, Anuhar, Goparaju, Ramya, Gupta, Charu, Weder, Julia, Klünemann, Thomas, Araujo Cruz, Michelle Maria, Kloos, Arnold, Goerlich, Kerstin, Schottmann, Renate, Othman, Basem, Struys, Eduard A., Bähre, Heike, Grote-Koska, Denis, Brand, Korbinian, Ganser, Arnold, Preller, Matthias, Heuser, Michael
Publicado no Leukemia (2019)

Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate

Por Chaturvedi, Anuhar, Araujo Cruz, Michelle Maria, Jyotsana, Nidhi, Sharma, Amit, Goparaju, Ramya, Schwarzer, Adrian, Görlich, Kerstin, Schottmann, Renate, Struys, Eduard A., Jansen, Erwin E., Rohde, Christian, Müller-Tidow, Carsten, Geffers, Robert, Göhring, Gudrun, Ganser, Arnold, Thol, Felicitas, Heuser, Michael
Publicado no Leukemia (2016)

TM-04 A TRANSGENIC ZEBRAFISH MODEL FOR GLIOMAS WITH MUTATIONS IN ISOCITRATE DEHYDROGENASE 1

Por Gao, Ya D., van der Linde, Herma C. Z., Struys, Eduard A., van Breugel, Valeska, de Wit, Maurice, Erdem, Lale, Bovée, Judith V.M.G., Lamfers, Martine L. M., Silleviss Smitt, Peter A.E., Salomons, Gajja S., Willemsen, Rob, French, Pim J.
Publicado no Neuro Oncol (2014)

D‐2‐hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants

Por Pop, Ana, Struys, Eduard A., Jansen, Erwin E. W., Fernandez, Matilde R., Kanhai, Warsha A., van Dooren, Silvy J. M., Ozturk, Senay, van Oostendorp, Justin, Lennertz, Pascal, Kranendijk, Martijn, van der Knaap, Marjo S., Gibson, K. Michael, van Schaftingen, Emile, Salomons, Gajja S.
Publicado no Hum Mutat (2019)

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

Por Suijker, Johnny, Oosting, Jan, Koornneef, Annemarie, Struys, Eduard A., Salomons, Gajja S., Schaap, Frank G., Waaijer, Cathelijn J.F., Wijers-Koster, Pauline M., Briaire-de Bruijn, Inge H., Haazen, Lizette, Riester, Scott M., Dudakovic, Amel, Danen, Erik, Cleton-Jansen, Anne-Marie, van Wijnen, Andre J., Bovée, Judith V.M.G.
Publicado no Oncotarget (2015)

Blood-based metabolic signatures in Alzheimer's disease

Por de Leeuw, Francisca A., Peeters, Carel F.W., Kester, Maartje I., Harms, Amy C., Struys, Eduard A., Hankemeier, Thomas, van Vlijmen, Herman W.T., van der Lee, Sven J., van Duijn, Cornelia M., Scheltens, Philip, Demirkan, Ayşe, van de Wiel, Mark A., van der Flier, Wiesje M., Teunissen, Charlotte E.
Publicado no Alzheimers Dement (Amst) (2017)