Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate

Canonical mutations in IDH1 and IDH2 produce high levels of the R-enantiomer of 2-hydroxyglutarate (R-2HG), which is a competitive inhibitor of αKG-dependent enzymes and a putative oncometabolite. Mutant IDH1 collaborates with HoxA9 to induce monocytic leukemia in vivo. We employed two mouse models...

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Gepubliceerd in:Leukemia
Hoofdauteurs: Chaturvedi, Anuhar, Araujo Cruz, Michelle Maria, Jyotsana, Nidhi, Sharma, Amit, Goparaju, Ramya, Schwarzer, Adrian, Görlich, Kerstin, Schottmann, Renate, Struys, Eduard A., Jansen, Erwin E., Rohde, Christian, Müller-Tidow, Carsten, Geffers, Robert, Göhring, Gudrun, Ganser, Arnold, Thol, Felicitas, Heuser, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5298178/
https://ncbi.nlm.nih.gov/pubmed/27063596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.71
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