IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis

INTRODUCTION: The gene encoding isocitrate dehydrogenase 1 (IDH1) is frequently mutated in several tumor types including gliomas. The most prevalent mutation in gliomas is a missense mutation leading to a substitution of arginine with histidine at the residue 132 (R132H). Wild type IDH1 catalyzes ox...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gao, Ya, de Wit, Maurice, Struys, Eduard A., van der Linde, Herma C. Z., Salomons, Gajja S., Lamfers, Martine L. M., Willemsen, Rob, Sillevis Smitt, Peter A. E., French, Pim J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023169/
https://ncbi.nlm.nih.gov/pubmed/29953513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199737
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