TMOD-25. MODELING IDH1-MUTATED GLIOMAS: GENERATION, CHARACTERIZATION AND THERAPEUTIC SENSITIVITIES OF SEVEN PATIENT-DERIVED IDH1-MUTANT GLIOMA CELL LINES

INTRODUCTION: In spite of significant attention IDH mutations have attracted in glioma research, in vitro model systems with endogenous IDH mutations remain scarce. Development of these models is crucial not only for unraveling the molecular mechanisms that contribute to this disease entity, but esp...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Verheul, Cassandra, Kers, Trisha, Van Der Kaaij, Mariëlle, Pierson, Tessa, Gao, Ya, Dirven, Clemens, Struys, Eduard, Salomons, Gajja, Leenstra, Sieger, French, Pim, Lamfers, Martine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216648/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1137
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