Lack of B and T cell reactivity towards IDH1(R132H) in blood and tumor tissue from LGG patients

PURPOSE: Mutations in the isocitrate dehydrogenase-1 gene (IDH1) occur at high frequency in grade II–III gliomas (LGGs). IDH1 mutations are somatic, missense and heterozygous affecting codon 132 in the catalytic pocket of the enzyme. In LGG, most mutations (90%) result in an arginine to histidine su...

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Bibliografiske detaljer
Udgivet i:J Neurooncol
Main Authors: Weenink, Bas, van Brakel, Mandy, Wijers, Rebecca, Sillevis Smitt, Peter A. E., French, Pim J., Debets, Reno
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2019
Fag:
Laboratory Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660510/
https://ncbi.nlm.nih.gov/pubmed/31240524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03228-6
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