Lack of B and T cell reactivity towards IDH1(R132H) in blood and tumor tissue from LGG patients

PURPOSE: Mutations in the isocitrate dehydrogenase-1 gene (IDH1) occur at high frequency in grade II–III gliomas (LGGs). IDH1 mutations are somatic, missense and heterozygous affecting codon 132 in the catalytic pocket of the enzyme. In LGG, most mutations (90%) result in an arginine to histidine su...

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Bibliografiset tiedot
Julkaisussa:J Neurooncol
Päätekijät: Weenink, Bas, van Brakel, Mandy, Wijers, Rebecca, Sillevis Smitt, Peter A. E., French, Pim J., Debets, Reno
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer US 2019
Aiheet:
Laboratory Investigation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6660510/
https://ncbi.nlm.nih.gov/pubmed/31240524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03228-6
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