Novel therapeutics in multiple myeloma

由 Stewart, A. Keith
出版 2012

What is the functional role of the thalidomide binding protein cereblon?

由 Chang, Xiu-bao, Stewart, A. Keith
出版 2011

Carfilzomib: a novel second-generation proteasome inhibitor

由 Khan, Meaghan L, Stewart, A Keith
出版 2011

SnapShot: Multiple Myeloma

由 Braggio, Esteban, Kortüm, K. Martin, Stewart, A. Keith
發表在 Cancer Cell (2015)

Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma

由 Zhu, Yuan Xiao, Kortuem, K. Martin, Stewart, A. Keith
出版 2012

Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma

由 Chang, Xiubao, Zhu, Yuanxiao, Shi, Changxin, Stewart, A. Keith
發表在 Acta Biochim Biophys Sin (Shanghai) (2014)

Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma

由 Chang, Xiubao, Xu, Qinqin, Hou, Yuexian, Li, Cynthia, Xu, Ye, Stewart, A. Keith
發表在 Int J Mol Sci (2017)

Melphalan, prednisone, and thalidomide vs melphalan, prednisone, and lenalidomide (ECOG E1A06) in untreated multiple myeloma

由 Stewart, A. Keith, Jacobus, Susanna, Fonseca, Rafael, Weiss, Matthias, Callander, Natalie S., Chanan-Khan, Asher A., Rajkumar, S. Vincent
發表在 Blood (2015)

A Phase Ib Study of the combination of Aurora Kinase Inhibitor alisertib (MLN8237) and bortezomib in Relapsed or Refractory Multiple Myeloma

由 Rosenthal, Allison, Kumar, Shaji, Hofmeister, Craig, Laubach, Jacob, Vij, Ravi, Dueck, Amylou, Gano, Katherine, Stewart, A. Keith
發表在 Br J Haematol (2015)

Proteasome inhibitors block Ikaros degradation by lenalidomide in multiple myeloma

由 Shi, Chang-Xin, Kortüm, Klaus Martin, Zhu, Yuan Xiao, Jedlowski, Patrick, Bruins, Laura, Braggio, Esteban, Stewart, A. Keith
發表在 Haematologica (2015)

Identification of molecular vulnerabilities in human multiple myeloma cells by RNAi lethality screening of the druggable genome

由 Tiedemann, Rodger E, Zhu, Yuan Xao, Schmidt, Jessica, Xin Shi, Chang, Sereduk, Chris, Yin, Hongwei, Mousses, Spyro, Stewart, A Keith
出版 2011

Proteasome subunits differentially control Myeloma cell viability and proteasome inhibitor sensitivity

由 Shi, Chang-Xin, Zhu, Yuan Xiao, Bruins, Laura A., de Campos, Cecilia Bonolo, Stewart, William, Braggio, Esteban, Stewart, A. Keith
發表在 Mol Cancer Res (2020)

A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies

由 O’Connor, Owen A., Stewart, A. Keith, Vallone, Marcy, Molineaux, Christopher J., Kunkel, Lori A., Gerecitano, John F., Orlowski, Robert Z.
出版 2009

Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma

由 Leung-Hagesteijn, Chungyee, Erdmann, Natalie, Cheung, Grace, Keats, Jonathan J, Stewart, A Keith, Reece, Donna, Chung, Kim Chan, Tiedemann, Rodger E
出版 2013

Systolic dysfunction associated with carfilzomib use in patients with multiple myeloma

由 Jain, Tania, Narayanasamy, Hemalatha, Mikhael, Joseph, Reeder, Craig B., Bergsagel, P. Leif, Mayo, Angela, Stewart, A. Keith, Mookadam, Farouk, Fonseca, Rafael
發表在 Blood Cancer J (2017)

Activity of 129 Single-Agent Drugs in 228 Phase I and II Clinical Trials in Multiple Myeloma

由 Kortuem, K. Martin, Zidich, Kaitlyn, Schuster, Steven R., Khan, Meaghan L., Jimenez-Zepeda, Victor H., Mikhael, Joseph R., Fonseca, Rafael, Stewart, A. Keith
出版 2013

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

由 Chesi, Marta, Matthews, Geoffrey M., Garbitt, Victoria M., Palmer, Stephen E., Shortt, Jake, Lefebure, Marcus, Stewart, A. Keith, Johnstone, Ricky W., Bergsagel, P. Leif
出版 2012

Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma

由 Kumar, Shaji K., LaPlant, Betsy, Chng, Wee Joo, Zonder, Jeffrey, Callander, Natalie, Fonseca, Rafael, Fruth, Briant, Roy, Vivek, Erlichman, Charles, Stewart, A. Keith
發表在 Blood (2015)

Cyclophosphamide-bortezomib-dexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis

由 Mikhael, Joseph R., Schuster, Steven R., Jimenez-Zepeda, Victor H., Bello, Nancy, Spong, Jacy, Reeder, Craig B., Stewart, A. Keith, Bergsagel, P. Leif, Fonseca, Rafael
出版 2012

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo

由 Tiedemann, Rodger E., Schmidt, Jessica, Keats, Jonathan J., Shi, Chang-Xin, Zhu, Yuan Xiao, Palmer, Stephen E., Mao, Xinliang, Schimmer, Aaron D., Stewart, A. Keith
出版 2009