Targeting histone deacetyalses in the treatment of B- and T-cell malignancies

Por Zain, Jasmine, O’Connor, Owen A.
Publicado em 2010

Safety and efficacy of pralatrexate in the treatment of patients with relapsed or refractory peripheral T-cell lymphoma

Por Marchi, Enrica, O’Connor, Owen A.
Publicado em 2012

Belinostat in patients with refractory or relapsed peripheral T-cell lymphoma: a perspective review

Por Sawas, Ahmed, Radeski, Dejan, O’Connor, Owen A.
Publicado no Ther Adv Hematol (2015)

Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma

Por Jain, Salvia, Diefenbach, Catherine, Zain, Jasmine, O’Connor, Owen A
Publicado em 2011

Propolis and its Active Component, Caffeic Acid Phenethyl Ester (CAPE), Modulate Breast Cancer Therapeutic Targets via an Epigenetically Mediated Mechanism of Action

Por Omene, Coral, Kalac, Matko, Wu, Jing, Marchi, Enrica, Frenkel, Krystyna, O’Connor, Owen A
Publicado em 2013

New Strategies in Peripheral T-cell lymphoma: Understanding Tumor Biology and Developing Novel Therapies

Por Dunleavy, Kieron, Piekarz, Richard L., Zain, Jasmine, Janik, John E., Wilson, Wyndham H., O’Connor, Owen A., Bates, Susan E.
Publicado em 2010

Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs

Por Heaney, Mark L., Gardner, Jeffrey R., Karasavvas, Nicos, Golde, David W., Scheinberg, David A., Smith, Emily A., O’Connor, Owen A.
Publicado em 2008

A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies

Por O’Connor, Owen A., Stewart, A. Keith, Vallone, Marcy, Molineaux, Christopher J., Kunkel, Lori A., Gerecitano, John F., Orlowski, Robert Z.
Publicado em 2009

The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: Curative effects of desoxyepothilones B and F against human tumor xenogra...

Por Chou, Ting-Chao, O'Connor, Owen A., Tong, William P., Guan, Yongbiao, Zhang, Zui-Guo, Stachel, Shawn J., Lee, Chulbom, Danishefsky, Samuel J.
Publicado em 2001

High rate of complete responses to immune checkpoint inhibitors in patients with relapsed or refractory Hodgkin lymphoma previously exposed to epigenetic therapy

Por Falchi, Lorenzo, Sawas, Ahmed, Deng, Changchun, Amengual, Jennifer E., Colbourn, Donald S., Lichtenstein, Emily A., Khan, Karen A., Schwartz, Lawrence H., O’Connor, Owen A.
Publicado no J Hematol Oncol (2016)

Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin

Por Horwitz, Steven M., Advani, Ranjana H., Bartlett, Nancy L., Jacobsen, Eric D., Sharman, Jeff P., O’Connor, Owen A., Siddiqi, Tanya, Kennedy, Dana A., Oki, Yasuhiro
Publicado no Blood (2014)

Brentuximab vedotin, an antibody–drug conjugate, in patients with CD30‐positive haematologic malignancies and hepatic or renal impairment

Por Zhao, Baiteng, Chen, Robert, O'Connor, Owen A., Gopal, Ajay K., Ramchandren, Radhakrishnan, Goy, Andre, Matous, Jeffrey V., Fasanmade, Adedigbo A., Manley, Thomas J., Han, Tae H.
Publicado no Br J Clin Pharmacol (2016)

HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL

Por Kalac, Matko, Scotto, Luigi, Marchi, Enrica, Amengual, Jennifer, Seshan, Venkatraman E., Bhagat, Govind, Ulahannan, Netha, Leshchenko, Violetta V., Temkin, Alexis M., Parekh, Samir, Tycko, Benjamin, O'Connor, Owen A.
Publicado em 2011

CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies

Por Han, Tae H., Gopal, Ajay K., Ramchandren, Radhakrishnan, Goy, Andre, Chen, Robert, Matous, Jeffrey V., Cooper, Maureen, Grove, Laurie E., Alley, Stephen C., Lynch, Carmel M., O’Connor, Owen A.
Publicado em 2013

Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

Por Zullo, Kelly M., Guo, Yige, Cooke, Laurence, Jirau-Serrano, Xavier, Mangone, Michael, Scotto, Luigi, Amengual, Jennifer E., Mao, Yinghui, Nandakumar, Renu, Cremers, Serge, Duong, Jimmy, Mahadevan, Daruka, O’Connor, Owen A.
Publicado no Clin Cancer Res (2015)

Safety and efficacy of brentuximab vedotin for Hodgkin lymphoma recurring after allogeneic stem cell transplantation

Por Gopal, Ajay K., Ramchandren, Radhakrishnan, O'Connor, Owen A., Berryman, Robert B., Advani, Ranjana H., Chen, Robert, Smith, Scott E., Cooper, Maureen, Rothe, Achim, Matous, Jeffrey V., Grove, Laurie E., Zain, Jasmine
Publicado em 2012

Prediction and Early Detection of Response by NMR Spectroscopy and Imaging

Por Lee, Seung-Cheol, Arias-Mendoza, Fernando, Poptani, Harish, Delikatny, E. James, Wasik, Mariusz, Marzec, Michal, Schuster, Stephen J., Nasta, Sunita D., Svoboda, Jakub, O’Connor, Owen A., Smith, Mitchell R., Glickson, Jerry D.
Publicado em 2012

Dual targeting of protein degradation pathways with the selective HDAC6 inhibitor, ACY-1215, and bortezomib is synergistic in lymphoma

Por Amengual, Jennifer E., Johannet, Paul, Lombardo, Maximilian, Zullo, Kelly, Hoehn, Daniela, Bhagat, Govind, Scotto, Luigi, Jirau-Serrano, Xavier, Radeski, Dejan, Heinen, Jennifer, Jiang, Hongfeng, Cremers, Serge, Zhang, Yuan, Jones, Simon, O’Connor, Owen A.
Publicado no Clin Cancer Res (2015)

Phase I Clinical, Pharmacokinetic, and Pharmacodynamic Study of KOS-862 (Epothilone D) in Patients with Advanced Solid Tumors and Lymphoma

Por Konner, Jason, Grisham, Rachel N., Park, Jae, O’Connor, Owen A., Cropp, Gillian, Johnson, Robert, Hannah, Alison L., Hensley, Martee L., Sabbatini, Paul, Miranov, Svetlana, Danishefsky, Samuel, Hyman, David, Spriggs, David R., Dupont, Jakob, Aghajanian, Carol
Publicado em 2011

Phase 2 Study of Weekly Bortezomib in Mantle Cell and Follicular Lymphoma

Por Gerecitano, John, Portlock, Carol, Moskowitz, Craig, Hamlin, Paul, Straus, David, Zelenetz, Andrew D., Zhang, Zhigang, Dumitrescu, Otilia, Debra, Sarasohn, Lin, Dorothy, Pappanicholaou, Jennifer, Cortelli, Barbara MacGregor, Neylon, Ellen, Hamelers, Rachel, Wright, John, O'Connor, Owen A.
Publicado em 2009