DIPG-56. PRECLINICAL STUDIES OF DIANHYDROGALACTITOL (VAL-083) IN DIPG, AS SINGLE AGENT OR AS A COMBINATION WITH RADIATION OR AZD1775

Yazar: Steino, Anne, Bacha, Jeffrey, Brown, Dennis, Mueller, Sabine
Yayımlandı Neuro Oncol (2018)

Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination

Yazar: Zhai, Beibei, Steinø, Anne, Bacha, Jeffrey, Brown, Dennis, Daugaard, Mads
Yayımlandı Cell Death Dis (2018)

ET-18 VAL-083 IS A NOVEL N(7) ALKYLATING AGENT THAT INHIBITS THE GROWTH OF GLIOMA STEM AND NON-STEM CULTURES, INCLUDING TEMOZOLOMIDE-RESISTANT LINES

Yazar: Fouse, Shaun, Steino, Anne, Butowski, Nicholas, Bacha, Jeffrey, Brown, Dennis, Costello, Joseph
Baskı/Yayın Bilgisi 2014

HGG-02. DIANHYDROGALACTITOL (VAL-083) OVERCOMES MGMT- AND P53-MEDIATED CHEMO-RESISTANCE AND DISPLAYS SYNERGY WITH TOPOISOMERASE INHIBITORS

Yazar: Zhai, Beibei, Steino, Anne, Bacha, Jeffrey, Brown, Dennis, Daugaard, Mads, Nicolaides, Theodore
Yayımlandı Neuro Oncol (2017)

EXTH-25. DIANHYDROGALACTITOL (VAL-083) REDUCES GLIOBLASTOMA TUMOR GROWTH IN VIVO, UPON BEVACIZUMAB-INDUCED HYPOXIA

Yazar: Golebiewska, Anna, Oudin, Anais, Steino, Anne, Niclou, Simone, Brown, Dennis, Bacha, Jeffrey
Yayımlandı Neuro Oncol (2018)

CSIG-02. VAL-083 INHIBITS PROLIFERATION OF A PANEL OF EIGHT GLIOBLASTOMA STEM CELL LINES: DOWNREGULATION OF BDR4 AS A NOVEL ANTI-NEOPLASTIC MECHANISM

Yazar: Fernandez, Elise, Steino, Anne, Lesser, Glenn, Bacha, Jeffrey, Brown, Dennis, Kwatra, Madan
Yayımlandı Neuro Oncol (2018)

PDTM-27. DIANHYDROGALACTITOL (VAL-083) OVERCOMES CHEMORESISTANCE IN PEDIATRIC MALIGNANT BRAIN TUMORS AND DISPLAYS SYNERGY WITH TOPOISOMERASE INHIBITORS

Yazar: Zhai, Beibei, Steino, Anne, Bacha, Jeffrey, Brown, Dennis, Zhang, Jie, Nicolaides, Theo, Daugaard, Mads
Yayımlandı Neuro Oncol (2017)

DIPG-38. DIANHYDROGALACTITOL (VAL-083) WITH AZD1775 INCREASES SURVIVAL IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG), IN VIVO

Yazar: Steino, Anne, Yang, Xiaodong, Kline, Cassie, Brown, Dennis, Bacha, Jeff, Liu, Lei, Mueller, Sabine
Yayımlandı Neuro Oncol (2019)

Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells

Yazar: Zhai, Beibei, Li, Yue, Kotapalli, Sudha Sravanti, Bacha, Jeffrey, Brown, Dennis, Steinø, Anne, Daugaard, Mads
Yayımlandı Cell Death Dis (2020)

EXTH-09. DIANHYDROGALACTITOL (VAL-083) HAS THE POTENTIAL TO OVERCOME MAJOR CHALLENGES IN THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Yazar: Steino, Anne, Zhai, BeiBei, Yang, Xiaodong, Kline, Cassie, Bacha, Jeffrey, Brown, Dennis, Daugaard, Mads, Mueller, Sabine
Yayımlandı Neuro Oncol (2018)

DRES-10. THE DISTINCT CYTOTOXIC MECHANISM OF DIANHYDROGALACTITOL (VAL-083) OVERCOMES CHEMORESISTANCE AND PROVIDES NEW OPPORTUNITIES FOR COMBINATION THERAPY IN THE TREATMENT OF GLIO...

Yazar: Zhai, Beibei, Golebiewska, Anna, He, Guangan, Steino, Anne, Bacha, Jeffrey, Brown, Dennis, Niclou, Simone, Siddik, Zahid, Daugaard, Mads
Yayımlandı Neuro Oncol (2017)

Oncofetal Chondroitin Sulfate: A Putative Therapeutic Target in Adult and Pediatric Solid Tumors

Yazar: Khazamipour, Nastaran, Al-Nakouzi, Nader, Oo, Htoo Zarni, Ørum-Madsen, Maj, Steino, Anne, Sorensen, Poul H, Daugaard, Mads
Yayımlandı Cells (2020)

ATNT-26 PHASE I/II STUDY OF DIANHYDROGALACTITOL IN PATIENTS WITH RECURRENT MALIGNANT GLIOMA

Yazar: Shih, Kent, Patel, Mahish, Butowski, Nicholas, Bacha, Jeffrey, Brown, Dennis, Steino, Anne, Schwartz, Richard, Kanekal, Sarath, Lopez, Lorena, Burris, Howard
Yayımlandı Neuro Oncol (2015)

ACTR-71. PHASE 1/2 STUDY OF DIANHYDROGALACTITOL (VAL-083) WITH RADIATION THERAPY IN PATIENTS WITH NEWLY DIAGNOSED, MGMT-UNMETHYLATED GLIOBLASTOMA

Yazar: Chen, Zhong-ping, Guo, Chengcheng, Bacha, Jeffrey, Steino, Anne, Langlands, John, Kwan, Claire, Kanekal, Sarath, Schwartz, Richard, Lopez, Lorena, Brown, Dennis
Yayımlandı Neuro Oncol (2018)

AT-53 PHASE I/II STUDY OF DIANHYDROGALACTITOL IN PATIENTS WITH RECURRENT MALIGNANT GLIOBLASTOMA MULTIFORME (GBM)

Yazar: Shih, Kent, Patel, Manish, Butowski, Nicholas, Bacha, Jeffrey, Brown, Dennis, Garner, William, Steino, Anne, Schwartz, Richard, Kanekal, Sarath, Lopez, Lorena, Burris, Howard A.
Yayımlandı Neuro Oncol (2014)

ACTR-50. CLINICAL TRIALS WITH DIANHYDROGALACTITOL (VAL-083) IN MGMT-UNMETHYLATED GLIOBLASTOMA

Yazar: Bacha, Jeffrey, Steino, Anne, Langlands, John, Kanekal, Sarath, Schwartz, Richard, Lopez, Lorena, O’Brien, Barbara J, Chen, Zhongping, Penas-Prado, Marta, Brown, Dennis
Yayımlandı Neuro Oncol (2017)

ACTR-27. PHASE 2 STUDY OF DIANHYDROGALACTITOL (VAL-083) IN PATIENTS WITH MGMT-UNMETHYLATED, BEVACIZUMAB-NAÏVE RECURRENT GLIOBLASTOMA

Yazar: O’Brien, Barbara, de Groot, John, Kamiya-Matsuoka, Carlos, Weathers, Shiao-Pei, Bacha, Jeffrey, Brown, Dennis, Steino, Anne, Langlands, John, Schwartz, Richard, Kanekal, Sarath, Lopez, Lorena, Penas-Prado, Marta
Yayımlandı Neuro Oncol (2018)

CTNI-76. PHASE 2 CLINICAL TRIAL OF VAL-083 IN NEWLY DIAGNOSED MGMT-UNMETHYLATED GBM

Yazar: Chen, Zhong-ping, Guo, Cheng-Cheng, Yang, Qun-ying, Wu, Shao-xiong, Li, Jia-Wei, Bacha, Jeffrey, Johnson, Greg, Langlands, John, Schwartz, Richard, Kwan, Claire, Kanekal, Sarath, Steino, Anne, Lopez, Lorena, Brown, Dennis
Yayımlandı Neuro Oncol (2020)

CTNI-72. PHASE 2 STUDY OF DIANHYDROGALACTITOL (VAL-083) IN PATIENTS WITH MGMT-UNMETHYLATED, BEVACIZUMAB-NAÏVE GLIOBLASTOMA IN THE RECURRENT AND ADJUVANT SETTING

Yazar: O’Brien, Barbara, Penas-Prado, Marta, Kamiya-Matsuoka, Carlos, Weathers, Shiao-Pei, Yung, W K Alfred, Loghin, Monica, Harrison, Rebecca, Majd, Nazanin, Bacha, Jeffrey, Brown, Dennis, Johnson, Greg, Langlands, John, Schwartz, Richard, Kanekal, Sarath, Steino, Anne, Lopez, Lorena, de Groot, John
Yayımlandı Neuro Oncol (2020)

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Yazar: Golebiewska, Anna, Hau, Ann-Christin, Oudin, Anaïs, Stieber, Daniel, Yabo, Yahaya A., Baus, Virginie, Barthelemy, Vanessa, Klein, Eliane, Bougnaud, Sébastien, Keunen, Olivier, Wantz, May, Michelucci, Alessandro, Neirinckx, Virginie, Muller, Arnaud, Kaoma, Tony, Nazarov, Petr V., Azuaje, Francisco, De Falco, Alfonso, Flies, Ben, Richart, Lorraine, Poovathingal, Suresh, Arns, Thais, Grzyb, Kamil, Mock, Andreas, Herold-Mende, Christel, Steino, Anne, Brown, Dennis, May, Patrick, Miletic, Hrvoje, Malta, Tathiane M., Noushmehr, Houtan, Kwon, Yong-Jun, Jahn, Winnie, Klink, Barbara, Tanner, Georgette, Stead, Lucy F., Mittelbronn, Michel, Skupin, Alexander, Hertel, Frank, Bjerkvig, Rolf, Niclou, Simone P.
Yayımlandı Acta Neuropathol (2020)