EXTH-09. DIANHYDROGALACTITOL (VAL-083) HAS THE POTENTIAL TO OVERCOME MAJOR CHALLENGES IN THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

OBJECTIVE: VAL-083 is a structurally unique bi-functional DNA targeting agent that readily crosses the blood-brain barrier and accumulates in brain tumor tissue. Herein we assess the activity of VAL-083 as single agent as well as in combination regimens including Wee1 Kinase inhibitor AZD1775 and ra...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Steino, Anne, Zhai, BeiBei, Yang, Xiaodong, Kline, Cassie, Bacha, Jeffrey, Brown, Dennis, Daugaard, Mads, Mueller, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217023/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.358
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