DIPG-38. DIANHYDROGALACTITOL (VAL-083) WITH AZD1775 INCREASES SURVIVAL IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG), IN VIVO

VAL-083 is a bi-functional DNA-targeting agent that crosses the blood-brain barrier and accumulates in brain tumors. VAL-083 induces interstrand crosslinks leading to DNA double-strand breaks and S/G2 cell-cycle arrest. We hypothesized that by inhibiting G2 checkpoint regulator kinase Wee1, cancer c...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Steino, Anne, Yang, Xiaodong, Kline, Cassie, Brown, Dennis, Bacha, Jeff, Liu, Lei, Mueller, Sabine
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Diffuse Intrinsic Pontine Glioma (DIPG)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477434/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.059
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