HGG-02. DIANHYDROGALACTITOL (VAL-083) OVERCOMES MGMT- AND P53-MEDIATED CHEMO-RESISTANCE AND DISPLAYS SYNERGY WITH TOPOISOMERASE INHIBITORS

The mortality rate of pediatric CNS cancer has not decreased as other pediatric cancers, and high-grade gliomas (HGG) are the main cause of death in children with brain tumors. Children with HGG have few therapeutic options and 5-year survival is less than 20%. Relapsed HGG have a uniformly fatal ou...

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Vydáno v:Neuro Oncol
Hlavní autoři: Zhai, Beibei, Steino, Anne, Bacha, Jeffrey, Brown, Dennis, Daugaard, Mads, Nicolaides, Theodore
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475066/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.091
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