Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301

od Knutson, Daniel E., Roni, Rashid, Mian, Yeunus, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
izdano v Org Process Res Dev (2020)

Rapid pH-dependent equilibrium of 4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate does not influence bioavailability

od Roni, Rashid, Li, Guanguan, Mikulsky, Brandon N., Knutson, Daniel E., Mian, Yeunus, Zahn, Nicolas M., Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
izdano v Mol Pharm (2020)

Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models

od Zahn, Nicolas M., Mikulsky, Brandon N., Roni, M. S. Rashid, Yocum, Gene T., Mian, Md Yeunus, Knutson, Daniel E., Cook, James M., Emala, Charles W., Stafford, Douglas C., Arnold, Leggy A.
izdano v ACS Pharmacol Transl Sci (2020)

A novel GABA(A) receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo

od Yocum, Gene T., Perez-Zoghbi, Jose F., Danielsson, Jennifer, Kuforiji, Aisha S., Zhang, Yi, Li, Guanguan, Rashid Roni, M. S., Kodali, Revathi, Stafford, Douglas C., Arnold, Leggy A., Cook, James M., Emala, Charles W.
izdano v Am J Physiol Lung Cell Mol Physiol (2019)

A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA(A) Receptor

od Li, Guanguan, Nieman, Amanda N., Mian, Md Yeunus, Zahn, Nicolas M., Mikulsky, Brandon N., Poe, Michael M., Methuku, Kashi R., Liu, Yongfeng, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
izdano v Molecules (2020)

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

od Clayton, Terry, Poe, Michael M., Rallapalli, Sundari, Biawat, Poonam, Savić, Miroslav M., Rowlett, James K., Gallos, George, Emala, Charles W., Kaczorowski, Catherine C., Stafford, Douglas C., Arnold, Leggy A., Cook, James M.
izdano v Int J Med Chem (2015)

MIDD0301 – A first-in-class anti-inflammatory asthma drug targets GABA(A) receptors without causing systemic immune suppression

od Zahn, Nicolas M., Huber, Alec T., Mikulsky, Brandon Nicholas, Stepanski, Mae Elizabeth, Kehoe, Alexander Scott, Li, Guanguan, Schussman, Melissa, Rashid Roni, M. S., Kodali, Revathi, Cook, James M., Stafford, Douglas C., Steeber, Douglas A., Arnold, Leggy A.
izdano v Basic Clin Pharmacol Toxicol (2019)

Targeting nitric oxide production in microglia with novel imidazodiazepines for non-sedative pain treatment

od Nieman, Amanda N., Li, Guanguan, Zahn, Nicolas M., Mian, Md Yeunus, Mikulsky, Brandon N., Hoffman, Dylan A., Wilcox, Taylor M., Kehoe, Alexander S., Luecke, Ian W., Poe, Michael M., Alvarez-Carbonell, David, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
izdano v ACS Chem Neurosci (2020)

Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments

od Jahan, Rajwana, Stephen, Michael Rajesh, Forkuo, Gloria S., Kodali, Revathi, Guthrie, Margaret L., Nieman, Amanda N., Yuan, Nina Y., Zahn, Nicolas M., Poe, Michael M., Li, Guanguan, Yu, Olivia B., Yocum, Gene T., Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
izdano v Eur J Med Chem (2016)

Synthesis and characterization of a novel gamma-aminobutyric acid type A (GABA(A)) receptor ligand that combines outstanding metabolic stability, pharmacokinetics, and anxiolytic e...

od Poe, Michael M., Methuku, Kashi Reddy, Li, Guanguan, Verma, Ashwini R., Teske, Kelly A., Stafford, Douglas C., Arnold, Leggy A., Cramer, Jeffrey W., Jones, Timothy M., Cerne, Rok, Krambis, Michael J., Witkin, Jeffrey M., Jambrina, Enrique, Rehman, Sabah, Ernst, Margot, Cook, James M., Schkeryantz, Jeffrey M.
izdano v J Med Chem (2016)

A novel orally available asthma drug candidate that reduces smooth muscle constriction and inflammation by targeting GABA(A) receptors in the lung

od Forkuo, Gloria S., Nieman, Amanda N., Kodali, Revathi, Zahn, Nicolas M., Li, Guanguan, Rashid Roni, M. S., Stephen, Michael Rajesh, Harris, Ted W., Jahan, Rajwana, Guthrie, Margaret L., Yu, Olivia B., Fisher, Janet L., Yocum, Gene T., Emala, Charles W., Steeber, Douglas A., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
izdano v Mol Pharm (2018)

Development of GABA(A) Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments

od Forkuo, Gloria S., Guthrie, Margaret L., Yuan, Nina Y., Nieman, Amanda N., Kodali, Revathi, Jahan, Rajwana, Stephen, Michael R., Yocum, Gene T., Treven, Marco, Poe, Michael M., Li, Guanguan, Yu, Olivia B., Hartzler, Benjamin D., Zahn, Nicolas M., Ernst, Margot, Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
izdano v Mol Pharm (2016)

Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABA(A) Receptor Modulators

od Forkuo, Gloria S., Nieman, Amanda N., Yuan, Nina Y., Kodali, Revathi, Yu, Olivia B., Zahn, Nicolas M., Jahan, Rajwana, Li, Guanguan, Stephen, Michael Rajesh, Guthrie, Margaret L., Poe, Michael M., Hartzler, Benjamin D., Harris, Ted W., Yocum, Gene T., Emala, Charles W., Steeber, Douglas A., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
izdano v Mol Pharm (2017)