Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301

by Knutson, Daniel E., Roni, Rashid, Mian, Yeunus, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
Published in Org Process Res Dev (2020)

Rapid pH-dependent equilibrium of 4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate does not influence bioavailability

by Roni, Rashid, Li, Guanguan, Mikulsky, Brandon N., Knutson, Daniel E., Mian, Yeunus, Zahn, Nicolas M., Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
Published in Mol Pharm (2020)

Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models

by Zahn, Nicolas M., Mikulsky, Brandon N., Roni, M. S. Rashid, Yocum, Gene T., Mian, Md Yeunus, Knutson, Daniel E., Cook, James M., Emala, Charles W., Stafford, Douglas C., Arnold, Leggy A.
Published in ACS Pharmacol Transl Sci (2020)

A novel GABA(A) receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo

by Yocum, Gene T., Perez-Zoghbi, Jose F., Danielsson, Jennifer, Kuforiji, Aisha S., Zhang, Yi, Li, Guanguan, Rashid Roni, M. S., Kodali, Revathi, Stafford, Douglas C., Arnold, Leggy A., Cook, James M., Emala, Charles W.
Published in Am J Physiol Lung Cell Mol Physiol (2019)

A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA(A) Receptor

by Li, Guanguan, Nieman, Amanda N., Mian, Md Yeunus, Zahn, Nicolas M., Mikulsky, Brandon N., Poe, Michael M., Methuku, Kashi R., Liu, Yongfeng, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
Published in Molecules (2020)

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

by Clayton, Terry, Poe, Michael M., Rallapalli, Sundari, Biawat, Poonam, Savić, Miroslav M., Rowlett, James K., Gallos, George, Emala, Charles W., Kaczorowski, Catherine C., Stafford, Douglas C., Arnold, Leggy A., Cook, James M.
Published in Int J Med Chem (2015)

MIDD0301 – A first-in-class anti-inflammatory asthma drug targets GABA(A) receptors without causing systemic immune suppression

by Zahn, Nicolas M., Huber, Alec T., Mikulsky, Brandon Nicholas, Stepanski, Mae Elizabeth, Kehoe, Alexander Scott, Li, Guanguan, Schussman, Melissa, Rashid Roni, M. S., Kodali, Revathi, Cook, James M., Stafford, Douglas C., Steeber, Douglas A., Arnold, Leggy A.
Published in Basic Clin Pharmacol Toxicol (2019)

Targeting nitric oxide production in microglia with novel imidazodiazepines for non-sedative pain treatment

by Nieman, Amanda N., Li, Guanguan, Zahn, Nicolas M., Mian, Md Yeunus, Mikulsky, Brandon N., Hoffman, Dylan A., Wilcox, Taylor M., Kehoe, Alexander S., Luecke, Ian W., Poe, Michael M., Alvarez-Carbonell, David, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
Published in ACS Chem Neurosci (2020)

Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments

by Jahan, Rajwana, Stephen, Michael Rajesh, Forkuo, Gloria S., Kodali, Revathi, Guthrie, Margaret L., Nieman, Amanda N., Yuan, Nina Y., Zahn, Nicolas M., Poe, Michael M., Li, Guanguan, Yu, Olivia B., Yocum, Gene T., Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
Published in Eur J Med Chem (2016)

Synthesis and characterization of a novel gamma-aminobutyric acid type A (GABA(A)) receptor ligand that combines outstanding metabolic stability, pharmacokinetics, and anxiolytic e...

by Poe, Michael M., Methuku, Kashi Reddy, Li, Guanguan, Verma, Ashwini R., Teske, Kelly A., Stafford, Douglas C., Arnold, Leggy A., Cramer, Jeffrey W., Jones, Timothy M., Cerne, Rok, Krambis, Michael J., Witkin, Jeffrey M., Jambrina, Enrique, Rehman, Sabah, Ernst, Margot, Cook, James M., Schkeryantz, Jeffrey M.
Published in J Med Chem (2016)

A novel orally available asthma drug candidate that reduces smooth muscle constriction and inflammation by targeting GABA(A) receptors in the lung

by Forkuo, Gloria S., Nieman, Amanda N., Kodali, Revathi, Zahn, Nicolas M., Li, Guanguan, Rashid Roni, M. S., Stephen, Michael Rajesh, Harris, Ted W., Jahan, Rajwana, Guthrie, Margaret L., Yu, Olivia B., Fisher, Janet L., Yocum, Gene T., Emala, Charles W., Steeber, Douglas A., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
Published in Mol Pharm (2018)

Development of GABA(A) Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments

by Forkuo, Gloria S., Guthrie, Margaret L., Yuan, Nina Y., Nieman, Amanda N., Kodali, Revathi, Jahan, Rajwana, Stephen, Michael R., Yocum, Gene T., Treven, Marco, Poe, Michael M., Li, Guanguan, Yu, Olivia B., Hartzler, Benjamin D., Zahn, Nicolas M., Ernst, Margot, Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
Published in Mol Pharm (2016)

Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABA(A) Receptor Modulators

by Forkuo, Gloria S., Nieman, Amanda N., Yuan, Nina Y., Kodali, Revathi, Yu, Olivia B., Zahn, Nicolas M., Jahan, Rajwana, Li, Guanguan, Stephen, Michael Rajesh, Guthrie, Margaret L., Poe, Michael M., Hartzler, Benjamin D., Harris, Ted W., Yocum, Gene T., Emala, Charles W., Steeber, Douglas A., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
Published in Mol Pharm (2017)