Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301

بواسطة Knutson, Daniel E., Roni, Rashid, Mian, Yeunus, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
الحاوية / القاعدة Org Process Res Dev (2020)

Rapid pH-dependent equilibrium of 4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate does not influence bioavailability

بواسطة Roni, Rashid, Li, Guanguan, Mikulsky, Brandon N., Knutson, Daniel E., Mian, Yeunus, Zahn, Nicolas M., Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
الحاوية / القاعدة Mol Pharm (2020)

Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models

بواسطة Zahn, Nicolas M., Mikulsky, Brandon N., Roni, M. S. Rashid, Yocum, Gene T., Mian, Md Yeunus, Knutson, Daniel E., Cook, James M., Emala, Charles W., Stafford, Douglas C., Arnold, Leggy A.
الحاوية / القاعدة ACS Pharmacol Transl Sci (2020)

A novel GABA(A) receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo

بواسطة Yocum, Gene T., Perez-Zoghbi, Jose F., Danielsson, Jennifer, Kuforiji, Aisha S., Zhang, Yi, Li, Guanguan, Rashid Roni, M. S., Kodali, Revathi, Stafford, Douglas C., Arnold, Leggy A., Cook, James M., Emala, Charles W.
الحاوية / القاعدة Am J Physiol Lung Cell Mol Physiol (2019)

A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA(A) Receptor

بواسطة Li, Guanguan, Nieman, Amanda N., Mian, Md Yeunus, Zahn, Nicolas M., Mikulsky, Brandon N., Poe, Michael M., Methuku, Kashi R., Liu, Yongfeng, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
الحاوية / القاعدة Molecules (2020)

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

بواسطة Clayton, Terry, Poe, Michael M., Rallapalli, Sundari, Biawat, Poonam, Savić, Miroslav M., Rowlett, James K., Gallos, George, Emala, Charles W., Kaczorowski, Catherine C., Stafford, Douglas C., Arnold, Leggy A., Cook, James M.
الحاوية / القاعدة Int J Med Chem (2015)

MIDD0301 – A first-in-class anti-inflammatory asthma drug targets GABA(A) receptors without causing systemic immune suppression

بواسطة Zahn, Nicolas M., Huber, Alec T., Mikulsky, Brandon Nicholas, Stepanski, Mae Elizabeth, Kehoe, Alexander Scott, Li, Guanguan, Schussman, Melissa, Rashid Roni, M. S., Kodali, Revathi, Cook, James M., Stafford, Douglas C., Steeber, Douglas A., Arnold, Leggy A.
الحاوية / القاعدة Basic Clin Pharmacol Toxicol (2019)

Targeting nitric oxide production in microglia with novel imidazodiazepines for non-sedative pain treatment

بواسطة Nieman, Amanda N., Li, Guanguan, Zahn, Nicolas M., Mian, Md Yeunus, Mikulsky, Brandon N., Hoffman, Dylan A., Wilcox, Taylor M., Kehoe, Alexander S., Luecke, Ian W., Poe, Michael M., Alvarez-Carbonell, David, Cook, James M., Stafford, Douglas C., Arnold, Leggy A.
الحاوية / القاعدة ACS Chem Neurosci (2020)

Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments

بواسطة Jahan, Rajwana, Stephen, Michael Rajesh, Forkuo, Gloria S., Kodali, Revathi, Guthrie, Margaret L., Nieman, Amanda N., Yuan, Nina Y., Zahn, Nicolas M., Poe, Michael M., Li, Guanguan, Yu, Olivia B., Yocum, Gene T., Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
الحاوية / القاعدة Eur J Med Chem (2016)

Synthesis and characterization of a novel gamma-aminobutyric acid type A (GABA(A)) receptor ligand that combines outstanding metabolic stability, pharmacokinetics, and anxiolytic e...

بواسطة Poe, Michael M., Methuku, Kashi Reddy, Li, Guanguan, Verma, Ashwini R., Teske, Kelly A., Stafford, Douglas C., Arnold, Leggy A., Cramer, Jeffrey W., Jones, Timothy M., Cerne, Rok, Krambis, Michael J., Witkin, Jeffrey M., Jambrina, Enrique, Rehman, Sabah, Ernst, Margot, Cook, James M., Schkeryantz, Jeffrey M.
الحاوية / القاعدة J Med Chem (2016)

A novel orally available asthma drug candidate that reduces smooth muscle constriction and inflammation by targeting GABA(A) receptors in the lung

بواسطة Forkuo, Gloria S., Nieman, Amanda N., Kodali, Revathi, Zahn, Nicolas M., Li, Guanguan, Rashid Roni, M. S., Stephen, Michael Rajesh, Harris, Ted W., Jahan, Rajwana, Guthrie, Margaret L., Yu, Olivia B., Fisher, Janet L., Yocum, Gene T., Emala, Charles W., Steeber, Douglas A., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
الحاوية / القاعدة Mol Pharm (2018)

Development of GABA(A) Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments

بواسطة Forkuo, Gloria S., Guthrie, Margaret L., Yuan, Nina Y., Nieman, Amanda N., Kodali, Revathi, Jahan, Rajwana, Stephen, Michael R., Yocum, Gene T., Treven, Marco, Poe, Michael M., Li, Guanguan, Yu, Olivia B., Hartzler, Benjamin D., Zahn, Nicolas M., Ernst, Margot, Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
الحاوية / القاعدة Mol Pharm (2016)

Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABA(A) Receptor Modulators

بواسطة Forkuo, Gloria S., Nieman, Amanda N., Yuan, Nina Y., Kodali, Revathi, Yu, Olivia B., Zahn, Nicolas M., Jahan, Rajwana, Li, Guanguan, Stephen, Michael Rajesh, Guthrie, Margaret L., Poe, Michael M., Hartzler, Benjamin D., Harris, Ted W., Yocum, Gene T., Emala, Charles W., Steeber, Douglas A., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
الحاوية / القاعدة Mol Pharm (2017)