Long-acting injectable antiretrovirals for HIV treatment and prevention

بواسطة Spreen, William R., Margolis, David A., Pottage, John C.
منشور في 2013

GSK1265744 Demonstrates Robust in Vitro Activity Against Various Clades of HIV-1

بواسطة Karmon, Sharon L., Mohri, Hiroshi, Spreen, William, Markowitz, Martin
الحاوية / القاعدة J Acquir Immune Defic Syndr (2015)

Formulation and pharmacology of long-acting cabotegravir

بواسطة Trezza, Christine, Ford, Susan L., Spreen, William, Pan, Rennan, Piscitelli, Stephen
الحاوية / القاعدة Curr Opin HIV AIDS (2015)

Effects of Etravirine on the Pharmacokinetics of the Integrase Inhibitor S/GSK1265744

بواسطة Ford, Susan L., Gould, Elizabeth, Chen, Shuguang, Lou, Yu, Dumont, Etienne, Spreen, William, Piscitelli, Stephen
منشور في 2013

Lack of Pharmacokinetic Interaction between Rilpivirine and Integrase Inhibitors Dolutegravir and GSK1265744

بواسطة Ford, Susan L., Gould, Elizabeth, Chen, Shuguang, Margolis, David, Spreen, William, Crauwels, Herta, Piscitelli, Stephen
منشور في 2013

1532. Population Pharmacokinetic (PPK) Modeling and Simulation of Long-Acting (LA) Cabotegravir (CAB) to Inform Strategies Following Dosing Interruptions in HIV-1-Infected Subjects

بواسطة Han, Kelong, Baker, Mark, Patel, Parul, Margolis, David, Spreen, William, Moore, Katy P, Ford, Susan L
الحاوية / القاعدة Open Forum Infect Dis (2019)

Pharmacokinetics of Cabotegravir in Subjects with Severe Renal Impairment

بواسطة Parasrampuria, Ridhi, Ford, Susan, Lou, Yu, Fu, Caifeng, Bakshi, Kalpana, Tenorio, Allan, Trezza, Christine, Spreen, William, Patel, Parul
الحاوية / القاعدة Open Forum Infect Dis (2017)

Effect of a High‐Fat Meal on the Pharmacokinetics of the HIV Integrase Inhibitor Cabotegravir

بواسطة Patel, Parul, Ford, Susan L., Lou, Yu, Bakshi, Kalpana, Tenorio, Allan R., Zhang, Zhiping, Pan, Rennan, Spreen, William
الحاوية / القاعدة Clin Pharmacol Drug Dev (2018)

Effect of Cabotegravir on Cardiac Repolarization in Healthy Subjects

بواسطة Lou, Yu, Buchanan, Ann M., Chen, Shuguang, Ford, Susan L., Gould, Elizabeth, Margolis, David, Spreen, William R., Patel, Parul
الحاوية / القاعدة Clin Pharmacol Drug Dev (2016)

Pharmacokinetics of Cabotegravir in Subjects with Moderate Hepatic Impairment

بواسطة Shaik, Jafar Sadik, Ford, Susan, Lou, Yu, Zhang, Zhiping, Bakshi, Kalpana, Tenorio, Allan, Trezza, Christine, Spreen, William, Patel, Parul
الحاوية / القاعدة Open Forum Infect Dis (2017)

1035. Patient-Reported Outcomes on Long-Acting Cabotegravir + Rilpivirine as Maintenance Therapy: FLAIR 96-Week Results

بواسطة Chounta, Vasiliki, Bernal, Enrique, Lombaard, Johan, Katner, Harold P, Walmsley, Sharon, Dorey, David, Spreen, William, Griffith, Sandy, Margolis, David
الحاوية / القاعدة Open Forum Infect Dis (2020)

Lack of effect of oral cabotegravir on the pharmacokinetics of a levonorgestrel/ethinyl oestradiol‐containing oral contraceptive in healthy adult women

بواسطة Trezza, Christine, Ford, Susan L., Gould, Elizabeth, Lou, Yu, Huang, Chuyun, Ritter, James M., Buchanan, Ann M., Spreen, William, Patel, Parul
الحاوية / القاعدة Br J Clin Pharmacol (2017)

A Phase I Study to Evaluate the Pharmacokinetics and Safety of Cabotegravir in Adults With Severe Renal Impairment and Healthy Matched Control Participants

بواسطة Parasrampuria, Ridhi, Ford, Susan L., Lou, Yu, Fu, Caifeng, Bakshi, Kalpana K., Tenorio, Allan R., Trezza, Christine, Spreen, William R., Patel, Parul
الحاوية / القاعدة Clin Pharmacol Drug Dev (2019)

552. Evaluation of Relationships Between UGT1A1 Genotypes and Cabotegravir Long-Acting Injection Pharmacokinetics Among HIV-Infected Subjects in the LATTE-2 Study

بواسطة Xue, Zhengyu, King, Karen S, Ford, Susan L, Lou, Yu, Bakshi, Kalpana K, Margolis, David A, Hughes, Arlene R, Spreen, William R, Patel, Parul
الحاوية / القاعدة Open Forum Infect Dis (2018)

A Phase 1 Study to Evaluate the Pharmacokinetics and Safety of Cabotegravir in Patients With Hepatic Impairment and Healthy Matched Controls

بواسطة Shaik, Jafar Sadik B., Ford, Susan L., Lou, Yu, Zhang, Zhiping, Bakshi, Kalpana K., Tenorio, Allan R., Trezza, Christine, Spreen, William R., Patel, Parul
الحاوية / القاعدة Clin Pharmacol Drug Dev (2019)

Evaluation of the effect of UGT1A1 polymorphisms on the pharmacokinetics of oral and long-acting injectable cabotegravir

بواسطة Patel, Parul, Xue, Zhengyu, King, Karen S, Parham, Laura, Ford, Susan, Lou, Yu, Bakshi, Kalpana K, Sutton, Kenneth, Margolis, David, Hughes, Arlene R, Spreen, William R
الحاوية / القاعدة J Antimicrob Chemother (2020)

2495. Pharmacokinetics of Cabotegravir (CAB) and Rilpivirine (RPV) Long-Acting (LA) Injectables in HIV-infected Individuals through 48 Weeks in the FLAIR and ATLAS Phase 3 Studies

بواسطة Patel, Parul, Ford, Susan L, Crauwels, Herta, Han, Kelong, Rossenu, Stefaan, Neyens, Martine, Griffith, Sandy, Hudson, Krischan J, Margolis, David, Baker, Mark, Williams, Peter, Spreen, William
الحاوية / القاعدة Open Forum Infect Dis (2019)

Association of Efavirenz Hypersusceptibility with Virologic Response in ACTG 368, a Randomized Trial of Abacavir (ABC) in Combination with Efavirenz (EFV) and Indinavir (IDV) in HI...

بواسطة Demeter, Lisa M., DeGruttola, Victor, Lustgarten, Stephanie, Bettendorf, Daniel, Fischl, Margaret, Eshleman, Susan, Spreen, William, Nguyen, Bach-Yen, Koval, Christine E., Eron, Joseph J., Hammer, Scott, Squires, Kathleen
منشور في 2008

2840. Long-term Efficacy, Safety, and Durability of CAB and RPV as Two Drug Oral Maintenance Therapy: LATTE Week 312 Results

بواسطة Margolis, David, Sutton, Kenneth, De Vente, Jerome, LeBlanc, Roger, DeJesus, Edwin, Smith, Graham, Mills, Anthony, Baril, Jean-Guy, St. Clair, Marty, Stancil, Britt, Williams, Peter, Spreen, William
الحاوية / القاعدة Open Forum Infect Dis (2019)

1021. HIV-1 RNA Blips and Low-Level Replication During Phase III/IIIb Cabotegravir + Rilpivirine Long-Acting Studies Are Similar to Oral 3-Drug Therapy and Not Associated with Week...

بواسطة Talarico, Christine L, Wu, Sterling, Upadhyay, Ojesh R, Clair, Marty St, Van Eygen, Veerle, Hudson, Krischan J, Griffith, Sandy, Harrington, Conn M, van Lunzen, Jan, Margolis, David, Spreen, William
الحاوية / القاعدة Open Forum Infect Dis (2020)