552. Evaluation of Relationships Between UGT1A1 Genotypes and Cabotegravir Long-Acting Injection Pharmacokinetics Among HIV-Infected Subjects in the LATTE-2 Study

BACKGROUND: Cabotegravir (CAB), an HIV integrase inhibitor primarily metabolized by UGT1A1, is in development as an oral tablet and long-acting (LA) intramuscular (IM) injection for the treatment and prevention of HIV infection. CAB LA has a prolonged absorption phase, typical of flip-flop PK, which...

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Publicado no:Open Forum Infect Dis
Main Authors: Xue, Zhengyu, King, Karen S, Ford, Susan L, Lou, Yu, Bakshi, Kalpana K, Margolis, David A, Hughes, Arlene R, Spreen, William R, Patel, Parul
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255463/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.560
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