Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function

por Mantesso, Simone, Geerts, Dirk, Spanholtz, Jan, Kučerová, Lucia
Publicado en Front Immunol (2020)

IL-12 Directs Further Maturation of Ex Vivo Differentiated NK Cells with Improved Therapeutic Potential

por Lehmann, Dorit, Spanholtz, Jan, Sturtzel, Caterina, Tordoir, Marleen, Schlechta, Bernhard, Groenewegen, Dirk, Hofer, Erhard
Publicado 2014

Extensive natural killer cell receptor phenotyping on NK and T cells discloses differences in RA and PsA, potentially mirroring diverse immunoregulatory functions

por van Bijnen, Sandra TA, Cossu, Marta, Preijers, Frank, Spanholtz, Jan, Dolstra, Harry, Radstake, Timothy RDJ
Publicado 2011

Improving the Outcome of Leukemia by Natural Killer Cell-Based Immunotherapeutic Strategies

por Chouaib, Salem, Pittari, Gianfranco, Nanbakhsh, Arash, El Ayoubi, Hanadi, Amsellem, Sophie, Bourhis, Jean-Henri, Spanholtz, Jan
Publicado 2014

Clinical-Grade Generation of Active NK Cells from Cord Blood Hematopoietic Progenitor Cells for Immunotherapy Using a Closed-System Culture Process

por Spanholtz, Jan, Preijers, Frank, Tordoir, Marleen, Trilsbeek, Carel, Paardekooper, Jos, de Witte, Theo, Schaap, Nicolaas, Dolstra, Harry
Publicado 2011

Ex Vivo Generated Natural Killer Cells Acquire Typical Natural Killer Receptors and Display a Cytotoxic Gene Expression Profile Similar to Peripheral Blood Natural Killer Cells

por Lehmann, Dorit, Spanholtz, Jan, Osl, Markus, Tordoir, Marleen, Lipnik, Karoline, Bilban, Martin, Schlechta, Bernhard, Dolstra, Harry, Hofer, Erhard
Publicado 2012

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

por Veluchamy, John P., Kok, Nina, van der Vliet, Hans J., Verheul, Henk M. W., de Gruijl, Tanja D., Spanholtz, Jan
Publicado en Front Immunol (2017)

High Log-Scale Expansion of Functional Human Natural Killer Cells from Umbilical Cord Blood CD34-Positive Cells for Adoptive Cancer Immunotherapy

por Spanholtz, Jan, Tordoir, Marleen, Eissens, Diana, Preijers, Frank, van der Meer, Arnold, Joosten, Irma, Schaap, Nicolaas, de Witte, Theo M., Dolstra, Harry
Publicado 2010

Defining Early Human NK Cell Developmental Stages in Primary and Secondary Lymphoid Tissues

por Eissens, Diana N., Spanholtz, Jan, van der Meer, Arnold, van Cranenbroek, Bram, Dolstra, Harry, Kwekkeboom, Jaap, Preijers, Frank W. M. B., Joosten, Irma
Publicado 2012

Natural Killer Cell Differentiation From Hematopoietic Stem Cells: A Comparative Analysis of Heparin and Stromal Cell Supported Methods

por Dezell, Steven A., Ahn, Yong-Oon, Spanholtz, Jan, Wang, Hongbo, Weeres, Matthew, Jackson, Scott, Cooley, Sarah, Dolstra, Harry, Miller, Jeffrey S., Verneris, Michael R.
Publicado 2011

Combined IL-15 and IL-12 drives the generation of CD34(+)-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer

por Cany, Jeannette, van der Waart, Anniek B, Spanholtz, Jan, Tordoir, Marleen, Jansen, Joop H, van der Voort, Robbert, Schaap, Nicolaas M, Dolstra, Harry
Publicado en Oncoimmunology (2015)

Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function

por Veluchamy, John P., Delso-Vallejo, María, Kok, Nina, Bohme, Fenna, Seggewiss-Bernhardt, Ruth, van der Vliet, Hans J., de Gruijl, Tanja D., Huppert, Volker, Spanholtz, Jan
Publicado en Sci Rep (2017)

Wnt3a Protein Reduces Growth Factor-Driven Expansion of Human Hematopoietic Stem and Progenitor Cells in Serum-Free Cultures

por Duinhouwer, Lucia E., Tüysüz, Nesrin, Rombouts, Elwin W. J. C., ter Borg, Mariette N. D., Mastrobattista, Enrico, Spanholtz, Jan, Cornelissen, Jan J., ten Berge, Derk, Braakman, Eric
Publicado en PLoS One (2015)

Combination of NK Cells and Cetuximab to Enhance Anti-Tumor Responses in RAS Mutant Metastatic Colorectal Cancer

por Veluchamy, John Pradeep, Spanholtz, Jan, Tordoir, Marleen, Thijssen, Victor L., Heideman, Daniëlle A. M., Verheul, Henk M. W., de Gruijl, Tanja D., van der Vliet, Hans J.
Publicado en PLoS One (2016)

The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development

por Post, Mirte, Cuapio, Angelica, Osl, Markus, Lehmann, Dorit, Resch, Ulrike, Davies, David M., Bilban, Martin, Schlechta, Bernhard, Eppel, Wolfgang, Nathwani, Amit, Stoiber, Dagmar, Spanholtz, Jan, Casanova, Emilio, Hofer, Erhard
Publicado en Front Immunol (2017)

Natural Killer Cells and Anti-Cancer Therapies: Reciprocal Effects on Immune Function and Therapeutic Response

por Toffoli, Elisa C., Sheikhi, Abdolkarim, Höppner, Yannick D., de Kok, Pita, Yazdanpanah-Samani, Mahsa, Spanholtz, Jan, Verheul, Henk M. W., van der Vliet, Hans J., de Gruijl, Tanja D.
Publicado en Cancers (Basel) (2021)

Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rg(null) Mice

por Cany, Jeannette, van der Waart, Anniek B., Tordoir, Marleen, Franssen, Gerben M., Hangalapura, Basav N., de Vries, Jolanda, Boerman, Otto, Schaap, Nicolaas, van der Voort, Robbert, Spanholtz, Jan, Dolstra, Harry
Publicado 2013

In Vivo Efficacy of Umbilical Cord Blood Stem Cell-Derived NK Cells in the Treatment of Metastatic Colorectal Cancer

por Veluchamy, John P., Lopez-Lastra, Silvia, Spanholtz, Jan, Bohme, Fenna, Kok, Nina, Heideman, Daniëlle A. M., Verheul, Henk M. W., Di Santo, James P., de Gruijl, Tanja D., van der Vliet, Hans J.
Publicado en Front Immunol (2017)

High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status

por Veluchamy, John P., Heeren, A. Marijne, Spanholtz, Jan, van Eendenburg, Jaap D. H., Heideman, Daniëlle A. M., Kenter, Gemma G., Verheul, Henk M., van der Vliet, Hans J., Jordanova, Ekaterina S., de Gruijl, Tanja D.
Publicado en Cancer Immunol Immunother (2016)