Combined IL-15 and IL-12 drives the generation of CD34(+)-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer

Adoptive transfer of allogeneic natural killer (NK) cells represents a promising treatment approach against cancer, including acute myeloid leukemia (AML). Previously, we reported a cytokine-based culture method for the generation of NK cell products with high cell number and purity. In this system,...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Cany, Jeannette, van der Waart, Anniek B, Spanholtz, Jan, Tordoir, Marleen, Jansen, Joop H, van der Voort, Robbert, Schaap, Nicolaas M, Dolstra, Harry
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485802/
https://ncbi.nlm.nih.gov/pubmed/26140247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1017701
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