Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell–like T cells with the ability to self-renew and differentiate into potent effector cells. Here, we investigated the in vivo existence of stem cell–like antigen-specific T cells in allogeneic stem cell tran...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: van der Waart, Anniek B., van de Weem, Noortje M. P., Maas, Frans, Kramer, Cynthia S. M., Kester, Michel G. D., Falkenburg, J. H. Frederik, Schaap, Nicolaas, Jansen, Joop H., van der Voort, Robbert, Gattinoni, Luca, Hobo, Willemijn, Dolstra, Harry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246043/
https://ncbi.nlm.nih.gov/pubmed/25336630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-578583
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