Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8(+) T cells

AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4(+) T cells is insufficiently explored. Previously, we and others showed that AKT-inhibition during ex vivo CD8(+) T cell expansion facilitates the generation of polyfunctional T cells with stem cell memory...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Mousset, Charlotte M., Hobo, Willemijn, de Ligt, Aafke, Baardman, Sjoerd, Schaap, Nicolaas P. M., Jansen, Joop H., van der Waart, Anniek B., Dolstra, Harry
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568704/
https://ncbi.nlm.nih.gov/pubmed/32504246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-020-02612-w
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