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Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8(+) T cells
AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4(+) T cells is insufficiently explored. Previously, we and others showed that AKT-inhibition during ex vivo CD8(+) T cell expansion facilitates the generation of polyfunctional T cells with stem cell memory...
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| Publicat a: | Cancer Immunol Immunother |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer Berlin Heidelberg
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7568704/ https://ncbi.nlm.nih.gov/pubmed/32504246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-020-02612-w |
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