High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status

Down-regulation of HLA in tumor cells, low numbers and dysfunctionality of NK cells are commonly observed in patients with end-stage cervical cancer. Adoptive transfer of high numbers of cytotoxic NK cells might be a promising treatment approach in this setting. Here, we explored the cytotoxic effic...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Veluchamy, John P., Heeren, A. Marijne, Spanholtz, Jan, van Eendenburg, Jaap D. H., Heideman, Daniëlle A. M., Kenter, Gemma G., Verheul, Henk M., van der Vliet, Hans J., Jordanova, Ekaterina S., de Gruijl, Tanja D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222919/
https://ncbi.nlm.nih.gov/pubmed/27783105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1919-1
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