Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia

Por Somerville, Tim D. D., Somervaille, Tim C. P.
Publicado no Mol Cell Oncol (2016)

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells

Por Lynch, J T, Somerville, T D D, Spencer, G J, Huang, X, Somervaille, T C P
Publicado em 2013

A personalised medicine approach for ponatinib-resistant chronic myeloid leukaemia

Por Korfi, K., Mandal, A., Furney, S. J., Wiseman, D., Somervaille, T. C. P., Marais, R.
Publicado no Ann Oncol (2015)

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors

Por Korfi, K, Smith, M, Swan, J, Somervaille, T C P, Dhomen, N, Marais, R
Publicado no Cell Death Dis (2016)

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

Por Liedtke, Michaela, Ayton, Paul M., Somervaille, Tim C. P., Smith, Kevin S., Cleary, Michael L.
Publicado em 2010

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential

Por Wong, Piu, Iwasaki, Masayuki, Somervaille, Tim C.P., So, Chai Wai Eric, Cleary, Michael L.
Publicado em 2007

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Por Wang, Zhong, Smith, Kevin S., Murphy, Mark, Piloto, Obdulio, Somervaille, Tim C. P., Cleary, Michael L.
Publicado em 2008

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

Por Huang, Xu, Spencer, Gary J, Lynch, James T, Ciceri, Filippo, Somerville, Tim D D, Somervaille, Tim C P
Publicado em 2013

The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression

Por Wong, Piu, Iwasaki, Masayuki, Somervaille, Tim C.P., Ficara, Francesca, Carico, Christine, Arnold, Christopher, Chen, Cheng-Zheng, Cleary, Michael L.
Publicado em 2010

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival

Por Jude, Julian G, Spencer, Gary J, Huang, Xu, Somerville, Tim D D, Jones, David R, Divecha, Nullin, Somervaille, Tim C P
Publicado em 2014

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

Por Somervaille, Tim C. P., Matheny, Christina J., Spencer, Gary J., Iwasaki, Masayuki, Rinn, John L., Witten, Daniela M., Chang, Howard Y., Shurtleff, Sheila A., Downing, James R., Cleary, Michael L.
Publicado em 2009

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia

Por Wiseman, Daniel H., Williams, Emma L., Wilks, Deepti P., Sun Leong, Hui, Somerville, Tim D. D., Dennis, Michael W., Struys, Eduard A., Bakkali, Abdellatif, Salomons, Gajja S., Somervaille, Tim C. P.
Publicado no Leukemia (2016)

Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

Por White, Daniel J., Unwin, Richard D., Bindels, Eric, Pierce, Andrew, Teng, Hsiang-Ying, Muter, Joanne, Greystoke, Brigit, Somerville, Tim D., Griffiths, John, Lovell, Simon, Somervaille, Tim C. P., Delwel, Ruud, Whetton, Anthony D., Meyer, Stefan
Publicado em 2013