Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

The EVI1 (ecotropic viral integration site 1) gene at 3q26 codes for a transcriptional regulator with an essential role in haematopoiesis. Overexpression of EVI1 in acute myeloid leukaemia (AML) is frequently associated with 3q26 rearrangements and confers extremely poor prognosis. EVI1 mediates tra...

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Main Authors: White, Daniel J., Unwin, Richard D., Bindels, Eric, Pierce, Andrew, Teng, Hsiang-Ying, Muter, Joanne, Greystoke, Brigit, Somerville, Tim D., Griffiths, John, Lovell, Simon, Somervaille, Tim C. P., Delwel, Ruud, Whetton, Anthony D., Meyer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680417/
https://ncbi.nlm.nih.gov/pubmed/23776681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066510
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