EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

The transcriptional regulator EVI1 has an essential role in early hematopoiesis and development. However, aberrantly high expression of EVI1 has potent oncogenic properties and confers poor prognosis and chemo-resistance in leukemia and solid tumors. To investigate to what extent EVI1 function might...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acids Res
Main Authors: Paredes, Roberto, Schneider, Marion, Stevens, Adam, White, Daniel J, Williamson, Andrew J K, Muter, Joanne, Pearson, Stella, Kelly, James R, Connors, Kathleen, Wiseman, Daniel H, Chadwick, John A, Löffler, Harald, Teng, Hsiang Ying, Lovell, Simon, Unwin, Richard, van de Vrugt, Henri J, Smith, Helen, Kustikova, Olga, Schambach, Axel, Somervaille, Tim C P, Pierce, Andrew, Whetton, Anthony D, Meyer, Stefan
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2018
נושאים:
Gene regulation, Chromatin and Epigenetics
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125627/
https://ncbi.nlm.nih.gov/pubmed/29939287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky536
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