EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

The transcriptional regulator EVI1 has an essential role in early development and haematopoiesis. However, acute myeloid leukaemia (AML) driven by aberrantly high EVI1 expression has very poor prognosis. To investigate the effects of post-translational modifications on EVI1 function, we carried out...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Paredes, Roberto, Kelly, James R., Geary, Bethany, Almarzouq, Batool, Schneider, Marion, Pearson, Stella, Narayanan, Prakrithi, Williamson, Andrew, Lovell, Simon C., Wiseman, Daniel H., Chadwick, John A., Jones, Nigel J., Kustikova, Olga, Schambach, Axel, Garner, Terence, Amaral, Fabio M. R., Pierce, Andrew, Stevens, Adam, Somervaille, Tim C. P., Whetton, Anthony D., Meyer, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576810/
https://ncbi.nlm.nih.gov/pubmed/33082307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03099-0
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