EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

The transcriptional regulator EVI1 has an essential role in early development and haematopoiesis. However, acute myeloid leukaemia (AML) driven by aberrantly high EVI1 expression has very poor prognosis. To investigate the effects of post-translational modifications on EVI1 function, we carried out...

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Publicat a:Cell Death Dis
Autors principals: Paredes, Roberto, Kelly, James R., Geary, Bethany, Almarzouq, Batool, Schneider, Marion, Pearson, Stella, Narayanan, Prakrithi, Williamson, Andrew, Lovell, Simon C., Wiseman, Daniel H., Chadwick, John A., Jones, Nigel J., Kustikova, Olga, Schambach, Axel, Garner, Terence, Amaral, Fabio M. R., Pierce, Andrew, Stevens, Adam, Somervaille, Tim C. P., Whetton, Anthony D., Meyer, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576810/
https://ncbi.nlm.nih.gov/pubmed/33082307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03099-0
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