Hemoglobin genetics: recent contributions of GWAS and gene editing

Por Smith, Elenoe C., Orkin, Stuart H.
Publicado no Hum Mol Genet (2016)

Hinge Residue I174 is Critical for Proper dNTP Selection by DNA Polymerase β

Por Yamtich, Jen, Starcevic, Daniela, Lauper, Julia, Smith, Elenoe, Shi, Idina, Rangarajan, Sneha, Jaeger, Joachim, Sweasy, Joann B.
Publicado em 2010

Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation

Por Smith, Elenoe C., Teixeira, Alexandra M., Chen, Rachel C., Wang, Lin, Gao, Yuan, Hahn, Katherine L., Krause, Diane S.
Publicado em 2013

Role of RhoA Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes

Por Gao, Yuan, Smith, Elenoe, Ker, Elmer, Campbell, Phil, Cheng, Ee-chun, Zou, Siying, Lin, Sharon, Wang, Lin, Halene, Stephanie, Krause, Diane S.
Publicado em 2012

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

Por Smith, Elenoe C., Thon, Jonathan N., Devine, Matthew T., Lin, Sharon, Schulz, Vincent P., Guo, Yanwen, Massaro, Stephanie A., Halene, Stephanie, Gallagher, Patrick, Italiano, Joseph E., Krause, Diane S.
Publicado em 2012

ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and Platelets

Por Truman, Lucy A., Bentley, Kevin L., Smith, Elenoe C., Massaro, Stephanie A., Gonzalez, David G., Haberman, Ann M., Hill, Myriam, Jones, Dennis, Min, Wang, Krause, Diane S., Ruddle, Nancy H.
Publicado em 2012

Strict in vivo specificity of the Bcl11a erythroid enhancer

Por Smith, Elenoe C., Luc, Sidinh, Croney, Donyell M., Woodworth, Mollie B., Greig, Luciano C., Fujiwara, Yuko, Nguyen, Minh, Sher, Falak, Macklis, Jeffrey D., Bauer, Daniel E., Orkin, Stuart H.
Publicado no Blood (2016)

Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2

Por Xie, Huafeng, Peng, Cong, Huang, Jialiang, Li, Bin E., Kim, Woojin, Smith, Elenoe C., Fujiwara, Yuko, Qi, Jun, Cheloni, Giulia, Das, Partha P., Nguyen, Minh, Li, Shaoguang, Bradner, James E., Orkin, Stuart H.
Publicado no Cancer Discov (2016)

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

Por Bauer, Daniel E., Kamran, Sophia C., Lessard, Samuel, Xu, Jian, Fujiwara, Yuko, Lin, Carrie, Shao, Zhen, Canver, Matthew C., Smith, Elenoe C., Pinello, Luca, Sabo, Peter J., Vierstra, Jeff, Voit, Richard A., Yuan, Guo-Cheng, Porteus, Matthew H., Stamatoyannopoulos, John A., Lettre, Guillaume, Orkin, Stuart H.
Publicado em 2013

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Por Canver, Matthew C., Smith, Elenoe C., Sher, Falak, Pinello, Luca, Sanjana, Neville E., Shalem, Ophir, Chen, Diane D., Schupp, Patrick G., Vinjamur, Divya S., Garcia, Sara P., Luc, Sidinh, Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Maeda, Takahiro, Yuan, Guo-Cheng, Feng, Zhang, Orkin, Stuart H., Bauer, Daniel E.
Publicado no Nature (2015)