Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors

av Lessard, Samuel, Beaudoin, Mélissa, Benkirane, Karim, Lettre, Guillaume
I publikationen Genome Med (2015)

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts

av Lessard, Samuel, Beaudoin, Mélissa, Orkin, Stuart H, Bauer, Daniel E, Lettre, Guillaume
I publikationen Hum Mol Genet (2018)

Frameshift indels introduced by genome editing can lead to in-frame exon skipping

av Lalonde, Simon, Stone, Oliver A., Lessard, Samuel, Lavertu, Adam, Desjardins, Jessica, Beaudoin, Mélissa, Rivas, Manuel, Stainier, Didier Y. R., Lettre, Guillaume
I publikationen PLoS One (2017)

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci

av Lessard, Samuel, Francioli, Laurent, Alfoldi, Jessica, Tardif, Jean-Claude, Ellinor, Patrick T., MacArthur, Daniel G., Lettre, Guillaume, Orkin, Stuart H., Canver, Matthew C.
I publikationen Proc Natl Acad Sci U S A (2017)

A saturating mutagenesis CRISPR-Cas9–mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs

av Canver, Matthew C., Tripathi, Pratibha, Bullen, Michael J., Olshansky, Moshe, Kumar, Yogesh, Wong, Lee H., Turner, Stephen J., Lessard, Samuel, Pinello, Luca, Orkin, Stuart H., Das, Partha Pratim
I publikationen J Biol Chem (2020)

Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients

av Nguyen, Albert, Mamarbachi, Maya, Turcot, Valérie, Lessard, Samuel, Yu, Carol, Luo, Xiaoyan, Lalongé, Julie, Hayami, Doug, Gayda, Mathieu, Juneau, Martin, Thorin-Trescases, Nathalie, Lettre, Guillaume, Nigam, Anil, Thorin, Eric
I publikationen PLoS One (2016)

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility

av Lessard, Samuel, Gatof, Emily Stern, Beaudoin, Mélissa, Schupp, Patrick G., Sher, Falak, Ali, Adnan, Prehar, Sukhpal, Kurita, Ryo, Nakamura, Yukio, Baena, Esther, Ledoux, Jonathan, Oceandy, Delvac, Bauer, Daniel E., Lettre, Guillaume
I publikationen J Clin Invest (2017)

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

av Bauer, Daniel E., Kamran, Sophia C., Lessard, Samuel, Xu, Jian, Fujiwara, Yuko, Lin, Carrie, Shao, Zhen, Canver, Matthew C., Smith, Elenoe C., Pinello, Luca, Sabo, Peter J., Vierstra, Jeff, Voit, Richard A., Yuan, Guo-Cheng, Porteus, Matthew H., Stamatoyannopoulos, John A., Lettre, Guillaume, Orkin, Stuart H.
Publicerad 2013

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

av Canver, Matthew C., Lessard, Samuel, Pinello, Luca, Wu, Yuxuan, Ilboudo, Yann, Stern, Emily N., Needleman, Austen J., Galactéros, Frédéric, Brugnara, Carlo, Kutlar, Abdullah, McKenzie, Colin, Reid, Marvin, Chen, Diane D., Das, Partha Pratim, Cole, Mitchel, Zeng, Jing, Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Lettre, Guillaume, Bauer, Daniel E., Orkin, Stuart H.
I publikationen Nat Genet (2017)

Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease

av Raffield, Laura M., Ulirsch, Jacob C., Naik, Rakhi P., Lessard, Samuel, Handsaker, Robert E., Jain, Deepti, Kang, Hyun M., Pankratz, Nathan, Auer, Paul L., Bao, Erik L., Smith, Joshua D., Lange, Leslie A., Lange, Ethan M., Li, Yun, Thornton, Timothy A., Young, Bessie A., Abecasis, Goncalo R., Laurie, Cathy C., Nickerson, Deborah A., McCarroll, Steven A., Correa, Adolfo, Wilson, James G., Lettre, Guillaume, Sankaran, Vijay G., Reiner, Alex P.
I publikationen PLoS Genet (2018)

Testing the role of predicted gene knockouts in human anthropometric trait variation

av Lessard, Samuel, Manning, Alisa K., Low-Kam, Cécile, Auer, Paul L., Giri, Ayush, Graff, Mariaelisa, Schurmann, Claudia, Yaghootkar, Hanieh, Luan, Jian'an, Esko, Tonu, Karaderi, Tugce, Bottinger, Erwin P., Lu, Yingchang, Carlson, Chris, Caulfield, Mark, Dubé, Marie-Pierre, Jackson, Rebecca D., Kooperberg, Charles, McKnight, Barbara, Mongrain, Ian, Peters, Ulrike, Reiner, Alex P., Rhainds, David, Sotoodehnia, Nona, Hirschhorn, Joel N., Scott, Robert A., Munroe, Patricia B., Frayling, Timothy M., Loos, Ruth J.F., North, Kari E., Edwards, Todd L., Tardif, Jean-Claude, Lindgren, Cecilia M., Lettre, Guillaume
I publikationen Hum Mol Genet (2016)

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

av Chami, Nathalie, Chen, Ming-Huei, Slater, Andrew J., Eicher, John D., Evangelou, Evangelos, Tajuddin, Salman M., Love-Gregory, Latisha, Kacprowski, Tim, Schick, Ursula M., Nomura, Akihiro, Giri, Ayush, Lessard, Samuel, Brody, Jennifer A., Schurmann, Claudia, Pankratz, Nathan, Yanek, Lisa R., Manichaikul, Ani, Pazoki, Raha, Mihailov, Evelin, Hill, W. David, Raffield, Laura M., Burt, Amber, Bartz, Traci M., Becker, Diane M., Becker, Lewis C., Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P., O’Donoghue, Michelle L., Crosslin, David R., de Denus, Simon, Dubé, Marie-Pierre, Elliott, Paul, Engström, Gunnar, Evans, Michele K., Floyd, James S., Fornage, Myriam, Gao, He, Greinacher, Andreas, Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hernesniemi, Jussi, Highland, Heather M., Hirschhorn, Joel N., Hofman, Albert, Irvin, Marguerite R., Kähönen, Mika, Lange, Ethan, Launer, Lenore J., Lehtimäki, Terho, Li, Jin, Liewald, David C.M., Linneberg, Allan, Liu, Yongmei, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Mathias, Rasika A., Melander, Olle, Metspalu, Andres, Mononen, Nina, Nalls, Mike A., Nickerson, Deborah A., Nikus, Kjell, O’Donnell, Chris J., Orho-Melander, Marju, Pedersen, Oluf, Petersmann, Astrid, Polfus, Linda, Psaty, Bruce M., Raitakari, Olli T., Raitoharju, Emma, Richard, Melissa, Rice, Kenneth M., Rivadeneira, Fernando, Rotter, Jerome I., Schmidt, Frank, Smith, Albert Vernon, Starr, John M., Taylor, Kent D., Teumer, Alexander, Thuesen, Betina H., Torstenson, Eric S., Tracy, Russell P., Tzoulaki, Ioanna, Zakai, Neil A., Vacchi-Suzzi, Caterina, van Duijn, Cornelia M., van Rooij, Frank J.A., Cushman, Mary, Deary, Ian J., Velez Edwards, Digna R., Vergnaud, Anne-Claire, Wallentin, Lars, Waterworth, Dawn M., White, Harvey D., Wilson, James G., Zonderman, Alan B., Kathiresan, Sekar, Grarup, Niels, Esko, Tõnu, Loos, Ruth J.F., Lange, Leslie A., Faraday, Nauder, Abumrad, Nada A., Edwards, Todd L., Ganesh, Santhi K., Auer, Paul L., Johnson, Andrew D., Reiner, Alexander P., Lettre, Guillaume
I publikationen Am J Hum Genet (2016)