Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors

por Lessard, Samuel, Beaudoin, Mélissa, Benkirane, Karim, Lettre, Guillaume
Publicado en Genome Med (2015)

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts

por Lessard, Samuel, Beaudoin, Mélissa, Orkin, Stuart H, Bauer, Daniel E, Lettre, Guillaume
Publicado en Hum Mol Genet (2018)

Frameshift indels introduced by genome editing can lead to in-frame exon skipping

por Lalonde, Simon, Stone, Oliver A., Lessard, Samuel, Lavertu, Adam, Desjardins, Jessica, Beaudoin, Mélissa, Rivas, Manuel, Stainier, Didier Y. R., Lettre, Guillaume
Publicado en PLoS One (2017)

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci

por Lessard, Samuel, Francioli, Laurent, Alfoldi, Jessica, Tardif, Jean-Claude, Ellinor, Patrick T., MacArthur, Daniel G., Lettre, Guillaume, Orkin, Stuart H., Canver, Matthew C.
Publicado en Proc Natl Acad Sci U S A (2017)

A saturating mutagenesis CRISPR-Cas9–mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs

por Canver, Matthew C., Tripathi, Pratibha, Bullen, Michael J., Olshansky, Moshe, Kumar, Yogesh, Wong, Lee H., Turner, Stephen J., Lessard, Samuel, Pinello, Luca, Orkin, Stuart H., Das, Partha Pratim
Publicado en J Biol Chem (2020)

Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients

por Nguyen, Albert, Mamarbachi, Maya, Turcot, Valérie, Lessard, Samuel, Yu, Carol, Luo, Xiaoyan, Lalongé, Julie, Hayami, Doug, Gayda, Mathieu, Juneau, Martin, Thorin-Trescases, Nathalie, Lettre, Guillaume, Nigam, Anil, Thorin, Eric
Publicado en PLoS One (2016)

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility

por Lessard, Samuel, Gatof, Emily Stern, Beaudoin, Mélissa, Schupp, Patrick G., Sher, Falak, Ali, Adnan, Prehar, Sukhpal, Kurita, Ryo, Nakamura, Yukio, Baena, Esther, Ledoux, Jonathan, Oceandy, Delvac, Bauer, Daniel E., Lettre, Guillaume
Publicado en J Clin Invest (2017)

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level

por Bauer, Daniel E., Kamran, Sophia C., Lessard, Samuel, Xu, Jian, Fujiwara, Yuko, Lin, Carrie, Shao, Zhen, Canver, Matthew C., Smith, Elenoe C., Pinello, Luca, Sabo, Peter J., Vierstra, Jeff, Voit, Richard A., Yuan, Guo-Cheng, Porteus, Matthew H., Stamatoyannopoulos, John A., Lettre, Guillaume, Orkin, Stuart H.
Publicado 2013

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

por Canver, Matthew C., Lessard, Samuel, Pinello, Luca, Wu, Yuxuan, Ilboudo, Yann, Stern, Emily N., Needleman, Austen J., Galactéros, Frédéric, Brugnara, Carlo, Kutlar, Abdullah, McKenzie, Colin, Reid, Marvin, Chen, Diane D., Das, Partha Pratim, Cole, Mitchel, Zeng, Jing, Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Lettre, Guillaume, Bauer, Daniel E., Orkin, Stuart H.
Publicado en Nat Genet (2017)

Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease

por Raffield, Laura M., Ulirsch, Jacob C., Naik, Rakhi P., Lessard, Samuel, Handsaker, Robert E., Jain, Deepti, Kang, Hyun M., Pankratz, Nathan, Auer, Paul L., Bao, Erik L., Smith, Joshua D., Lange, Leslie A., Lange, Ethan M., Li, Yun, Thornton, Timothy A., Young, Bessie A., Abecasis, Goncalo R., Laurie, Cathy C., Nickerson, Deborah A., McCarroll, Steven A., Correa, Adolfo, Wilson, James G., Lettre, Guillaume, Sankaran, Vijay G., Reiner, Alex P.
Publicado en PLoS Genet (2018)

Testing the role of predicted gene knockouts in human anthropometric trait variation

por Lessard, Samuel, Manning, Alisa K., Low-Kam, Cécile, Auer, Paul L., Giri, Ayush, Graff, Mariaelisa, Schurmann, Claudia, Yaghootkar, Hanieh, Luan, Jian'an, Esko, Tonu, Karaderi, Tugce, Bottinger, Erwin P., Lu, Yingchang, Carlson, Chris, Caulfield, Mark, Dubé, Marie-Pierre, Jackson, Rebecca D., Kooperberg, Charles, McKnight, Barbara, Mongrain, Ian, Peters, Ulrike, Reiner, Alex P., Rhainds, David, Sotoodehnia, Nona, Hirschhorn, Joel N., Scott, Robert A., Munroe, Patricia B., Frayling, Timothy M., Loos, Ruth J.F., North, Kari E., Edwards, Todd L., Tardif, Jean-Claude, Lindgren, Cecilia M., Lettre, Guillaume
Publicado en Hum Mol Genet (2016)

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

por Chami, Nathalie, Chen, Ming-Huei, Slater, Andrew J., Eicher, John D., Evangelou, Evangelos, Tajuddin, Salman M., Love-Gregory, Latisha, Kacprowski, Tim, Schick, Ursula M., Nomura, Akihiro, Giri, Ayush, Lessard, Samuel, Brody, Jennifer A., Schurmann, Claudia, Pankratz, Nathan, Yanek, Lisa R., Manichaikul, Ani, Pazoki, Raha, Mihailov, Evelin, Hill, W. David, Raffield, Laura M., Burt, Amber, Bartz, Traci M., Becker, Diane M., Becker, Lewis C., Boerwinkle, Eric, Bork-Jensen, Jette, Bottinger, Erwin P., O’Donoghue, Michelle L., Crosslin, David R., de Denus, Simon, Dubé, Marie-Pierre, Elliott, Paul, Engström, Gunnar, Evans, Michele K., Floyd, James S., Fornage, Myriam, Gao, He, Greinacher, Andreas, Gudnason, Vilmundur, Hansen, Torben, Harris, Tamara B., Hayward, Caroline, Hernesniemi, Jussi, Highland, Heather M., Hirschhorn, Joel N., Hofman, Albert, Irvin, Marguerite R., Kähönen, Mika, Lange, Ethan, Launer, Lenore J., Lehtimäki, Terho, Li, Jin, Liewald, David C.M., Linneberg, Allan, Liu, Yongmei, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Mathias, Rasika A., Melander, Olle, Metspalu, Andres, Mononen, Nina, Nalls, Mike A., Nickerson, Deborah A., Nikus, Kjell, O’Donnell, Chris J., Orho-Melander, Marju, Pedersen, Oluf, Petersmann, Astrid, Polfus, Linda, Psaty, Bruce M., Raitakari, Olli T., Raitoharju, Emma, Richard, Melissa, Rice, Kenneth M., Rivadeneira, Fernando, Rotter, Jerome I., Schmidt, Frank, Smith, Albert Vernon, Starr, John M., Taylor, Kent D., Teumer, Alexander, Thuesen, Betina H., Torstenson, Eric S., Tracy, Russell P., Tzoulaki, Ioanna, Zakai, Neil A., Vacchi-Suzzi, Caterina, van Duijn, Cornelia M., van Rooij, Frank J.A., Cushman, Mary, Deary, Ian J., Velez Edwards, Digna R., Vergnaud, Anne-Claire, Wallentin, Lars, Waterworth, Dawn M., White, Harvey D., Wilson, James G., Zonderman, Alan B., Kathiresan, Sekar, Grarup, Niels, Esko, Tõnu, Loos, Ruth J.F., Lange, Leslie A., Faraday, Nauder, Abumrad, Nada A., Edwards, Todd L., Ganesh, Santhi K., Auer, Paul L., Johnson, Andrew D., Reiner, Alexander P., Lettre, Guillaume
Publicado en Am J Hum Genet (2016)