Frameshift indels introduced by genome editing can lead to in-frame exon skipping

The introduction of frameshift indels by genome editing has emerged as a powerful technique to study the functions of uncharacterized genes in cell lines and model organisms. Such mutations should lead to mRNA degradation owing to nonsense-mediated mRNA decay or the production of severely truncated...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lalonde, Simon, Stone, Oliver A., Lessard, Samuel, Lavertu, Adam, Desjardins, Jessica, Beaudoin, Mélissa, Rivas, Manuel, Stainier, Didier Y. R., Lettre, Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453576/
https://ncbi.nlm.nih.gov/pubmed/28570605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178700
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