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Predicting the effects of frameshifting indels

Each human has approximately 50 to 280 frameshifting indels, yet their implications are unknown. We created SIFT Indel, a prediction method for frameshifting indels that has 84% accuracy. The percentage of human frameshifting indels predicted to be gene-damaging is negatively correlated with allele...

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Autores principales: Hu, Jing, Ng, Pauline C
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334572/
https://ncbi.nlm.nih.gov/pubmed/22322200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-2-r9
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