Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation

How components of the cytoskeleton regulate complex cellular responses is fundamental to understanding cellular function. Megakaryoblast leukemia 1 (MKL1), an activator of serum response factor (SRF) transcriptional activity, promotes muscle, neuron, and megakaryocyte differentiation. In muscle cell...

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Detalhes bibliográficos
Main Authors: Smith, Elenoe C., Teixeira, Alexandra M., Chen, Rachel C., Wang, Lin, Gao, Yuan, Hahn, Katherine L., Krause, Diane S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575755/
https://ncbi.nlm.nih.gov/pubmed/23243284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-429993
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