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Role of RhoA Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes
Polyploidization can precede the development of aneuploidy in cancer. Polyploidization in megakaryocytes (Mk), in contrast, is a highly controlled developmental process critical for efficient platelet production via unknown mechanisms. Using primary cells, we demonstrate that the guanine exchange fa...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306542/ https://ncbi.nlm.nih.gov/pubmed/22387001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.12.019 |
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