MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

Serum response factor and its transcriptional cofactor MKL1 are critical for megakaryocyte maturation and platelet formation. We show that MKL2, a homologue of MKL1, is expressed in megakaryocytes and plays a role in megakaryocyte maturation. Using a megakaryocyte-specific Mkl2 knockout (KO) mouse o...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Smith, Elenoe C., Thon, Jonathan N., Devine, Matthew T., Lin, Sharon, Schulz, Vincent P., Guo, Yanwen, Massaro, Stephanie A., Halene, Stephanie, Gallagher, Patrick, Italiano, Joseph E., Krause, Diane S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447785/
https://ncbi.nlm.nih.gov/pubmed/22806889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-420828
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky