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MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation
Serum response factor and its transcriptional cofactor MKL1 are critical for megakaryocyte maturation and platelet formation. We show that MKL2, a homologue of MKL1, is expressed in megakaryocytes and plays a role in megakaryocyte maturation. Using a megakaryocyte-specific Mkl2 knockout (KO) mouse o...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3447785/ https://ncbi.nlm.nih.gov/pubmed/22806889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-420828 |
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