MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

Serum response factor and its transcriptional cofactor MKL1 are critical for megakaryocyte maturation and platelet formation. We show that MKL2, a homologue of MKL1, is expressed in megakaryocytes and plays a role in megakaryocyte maturation. Using a megakaryocyte-specific Mkl2 knockout (KO) mouse o...

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Detalhes bibliográficos
Main Authors: Smith, Elenoe C., Thon, Jonathan N., Devine, Matthew T., Lin, Sharon, Schulz, Vincent P., Guo, Yanwen, Massaro, Stephanie A., Halene, Stephanie, Gallagher, Patrick, Italiano, Joseph E., Krause, Diane S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447785/
https://ncbi.nlm.nih.gov/pubmed/22806889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-420828
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