Serum response factor is an essential transcription factor in megakaryocytic maturation

Serum response factor (Srf) is a MADS–box transcription factor that is critical for muscle differentiation. Its function in hematopoiesis has not yet been revealed. Mkl1, a cofactor of Srf, is part of the t(1;22) translocation in acute megakaryoblastic leukemia, and plays a critical role in megakary...

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Autori principali: Halene, Stephanie, Gao, Yuan, Hahn, Katherine, Massaro, Stephanie, Italiano, Joseph E., Schulz, Vincent, Lin, Sharon, Kupfer, Gary M., Krause, Diane S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Platelets and Thrombopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173990/
https://ncbi.nlm.nih.gov/pubmed/20525922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-261743
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