Insights about Striatal Circuit Function and Schizophrenia from a Mouse Model of D2 Receptor Upregulation

Por Simpson, Eleanor H., Kellendonk, Christoph
Publicado no Biol Psychiatry (2016)

The Behavioral Neuroscience of Motivation: An Overview of Concepts, Measures, and Translational Applications

Por Simpson, Eleanor H., Balsam, Peter D.
Publicado no Curr Top Behav Neurosci (2016)

A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia

Por Simpson, Eleanor H., Kellendonk, Christoph, Kandel, Eric
Publicado no Neuron (2010)

Modeling cognitive endophenotypes of schizophrenia in mice

Por Kellendonk, Christoph, Simpson, Eleanor H., Kandel, Eric R.
Publicado no Trends Neurosci (2009)

Neural Substrates Underlying Effort, Time, and Risk-Based Decision Making in Motivated Behavior

Por Bailey, Matthew R., Simpson, Eleanor H., Balsam, Peter D
Publicado no Neurobiol Learn Mem (2016)

Schizophrenia in Translation: Dissecting Motivation in Schizophrenia and Rodents

Por Simpson, Eleanor H., Waltz, James A., Kellendonk, Christoph, Balsam, Peter D.
Publicado em 2012

Modeling Motivational Deficits in Mouse Models of Schizophrenia: Behavior Analysis as a Guide for Neuroscience

Por Ward, Ryan D., Simpson, Eleanor H., Kandel, Eric R., Balsam, Peter D
Publicado em 2011

D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex

Por Li, Yan-Chun, Kellendonk, Christoph, Simpson, Eleanor H., Kandel, Eric R., Gao, Wen-Jun
Publicado em 2011

Orbitofrontal cortex mediates the differential impact of signaled-reward probability on discrimination accuracy

Por Ward, Ryan D., Winiger, Vanessa, Kandel, Eric R., Balsam, Peter D, Simpson, Eleanor H.
Publicado no Front Neurosci (2015)

Selective Overexpression of Dopamine D3 Receptors in the Striatum Disrupts Motivation but not Cognition

Por Simpson, Eleanor H., Winiger, Vanessa, Biezonski, Dominik K., Haq, Iram, Kandel, Eric R., Kellendonk, Christoph
Publicado em 2013

Transient and selective overexpression of D(2) receptors in the striatum causes persistent deficits in conditional associative learning

Por Bach, Mary-Elizabeth, Simpson, Eleanor H., Kahn, Lora, Marshall, John J., Kandel, Eric R., Kellendonk, Christoph
Publicado em 2008

Improving Temporal Cognition by Enhancing Motivation

Por Avlar, Billur, Kahn, Julia B., Jensen, Greg, Kandel, Eric R., Simpson, Eleanor H., Balsam, Peter D.
Publicado no Behav Neurosci (2015)

The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice

Por Bailey, Matthew R., Williamson, Cait, Mezias, Chris, Winiger, Vanessa, Silver, Rae, Balsam, Peter D., Simpson, Eleanor H.
Publicado no Psychopharmacology (Berl) (2015)

A Novel Strategy for Dissecting Goal-Directed Action and Arousal Components of Motivated Behavior with a Progressive Hold Down Task

Por Bailey, Matthew R., Jensen, Greg, Taylor, Kathleen, Mezias, Chris, Williamson, Cait, Silver, Rae, Simpson, Eleanor H., Balsam, Peter D
Publicado no Behav Neurosci (2015)

Pharmacologic Rescue of Motivational Deficit in an Animal Model of the Negative Symptoms of Schizophrenia

Por Simpson, Eleanor H., Kellendonk, Christoph, Ward, Ryan D., Richards, Vanessa, Lipatova, Olga, Fairhurst, Stephen, Kandel, Eric R., Balsam, Peter D.
Publicado em 2011

Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area

Por Krabbe, Sabine, Duda, Johanna, Schiemann, Julia, Poetschke, Christina, Schneider, Gaby, Kandel, Eric R., Liss, Birgit, Roeper, Jochen, Simpson, Eleanor H.
Publicado no Proc Natl Acad Sci U S A (2015)

The impact of motivation on cognitive performance in an animal model of the negative and cognitive symptoms of schizophrenia

Por Ward, Ryan D., Winiger, Vanessa, Higa, Kerin K., Kahn, Julia B., Kandel, Eric R., Balsam, Peter D, Simpson, Eleanor H.
Publicado no Behav Neurosci (2015)

Impaired Timing Precision Produced by Striatal D2 Receptor Overexpression is Mediated by Cognitive and Motivational Deficits

Por Ward, Ryan D., Kellendonk, Christoph, Simpson, Eleanor H., Lipatova, Olga, Drew, Michael R., Fairhurst, Stephen, Kandel, Eric R., Balsam, Peter D
Publicado em 2009

Medial prefrontal lesions in mice impair sustained attention but spare maintenance of information in working memory

Por Kahn, Julia B., Ward, Ryan D., Kahn, Lora W., Rudy, Nicole M., Kandel, Eric R., Balsam, Peter D., Simpson, Eleanor H.
Publicado em 2012

Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia

Por Ward, Ryan D, Simpson, Eleanor H, Richards, Vanessa L, Deo, Gita, Taylor, Kathleen, Glendinning, John I, Kandel, Eric R, Balsam, Peter D
Publicado em 2012