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Transient and selective overexpression of D(2) receptors in the striatum causes persistent deficits in conditional associative learning
Cognitive deficits in schizophrenia are thought to derive from a hypofunction of the prefrontal cortex (PFC), but the origin of the hypofunction is unclear. To explore the nature of this deficit, we genetically modified mice to model the increase in striatal dopamine D(2) receptors (D(2)Rs) observed...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572912/ https://ncbi.nlm.nih.gov/pubmed/18832466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807746105 |
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