Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum

A common genetic polymorphism that results in increased activity of the dopamine regulating enzyme COMT (the COMT Val(158) allele) has been found to associate with poorer cognitive performance and increased susceptibility to develop psychiatric disorders. It is generally assumed that this increase i...

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Detalhes bibliográficos
Main Authors: Simpson, Eleanor H., Morud, Julia, Winiger, Vanessa, Biezonski, Dominik, Zhu, Judy P., Bach, Mary Elizabeth, Malleret, Gael, Polan, H. Jonathan, Ng-Evans, Scott, Phillips, Paul E.M., Kellendonk, Christoph, Kandel, Eric R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966542/
https://ncbi.nlm.nih.gov/pubmed/24639487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.032094.113
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