Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area

There is strong evidence that the core deficits of schizophrenia result from dysfunction of the dopamine (DA) system, but details of this dysfunction remain unclear. We previously reported a model of transgenic mice that selectively and reversibly overexpress DA D2 receptors (D2Rs) in the striatum (...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Krabbe, Sabine, Duda, Johanna, Schiemann, Julia, Poetschke, Christina, Schneider, Gaby, Kandel, Eric R., Liss, Birgit, Roeper, Jochen, Simpson, Eleanor H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378386/
https://ncbi.nlm.nih.gov/pubmed/25675529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500450112
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